PREP, prolyl endopeptidase, 5550

N. diseases: 105; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.080 GeneticVariation phenotype BEFREE 2011, while indexes of parasympathetic (i.e., respiratory sinus arrhythmia [RSA]) and sympathetic (i.e., pre-ejection period [PEP] and electrodermal activity [EDA]) reactivity were obtained. 31808007 2020
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.080 GeneticVariation phenotype BEFREE We hypothesized that CAB/CAR would more reliably index post-traumatic stress (PTS) responses compared to measuring the parasympathetic (i.e., respiratory sinus arrhythmia; RSA) and sympathetic (i.e., pre-ejection period; PEP) nervous systems in isolation. 31740215 2020
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.080 GeneticVariation phenotype BEFREE The current study utilized a diverse sample of school-aged children (N = 169; 47.9% female; 47.3% Latinx) to evaluate relations between children's parasympathetic (i.e., respiratory sinus arrhythmia; RSA) and sympathetic (i.e., pre-ejection period; PEP) reactivity in response to each of three film-elicited emotion challenges (i.e., sadness, happiness, and fear) at age 7 and both observed and parent-reported prosocial behavior one year later. 31523938 2019
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.080 Biomarker phenotype BEFREE We examined children's (N = 278) sympathetic (preejection period [PEP]) and parasympathetic (respiratory sinus arrhythmia [RSA]) responses to cognitive (i.e., problem-solving and cognitive control) and negatively valenced emotional (i.e., blocked goal and unfairness) challenges in preschool, kindergarten, and grade 1. 31578722 2019
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.080 GeneticVariation phenotype BEFREE A baby cry-response task was administered during pregnancy while indicators of sympathetic reactivity (pre-ejection period; PEP) and parasympathetic reactivity (respiratory sinus arrhythmia; RSA) were recorded. 30585566 2018
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.080 Biomarker phenotype BEFREE This study examined the effects of 6-year-olds' (N = 198; 49.5% female; 46% Latinx) capacity for ANS reactivity and recovery in both sympathetic (i.e., pre-ejection period [PEP]) and parasympathetic (i.e., respiratory sinus arrhythmia [RSA]) systems on their caregiver- and examiner-reported adaptability and attention problems at age 8. 30370630 2018
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.080 AlteredExpression phenotype BEFREE To address this, autonomic measures of sympathetic (cardiac pre-ejection period, PEP; electrodermal activity, and EDA) and parasympathetic (respiratory sinus arrhythmia and RSA) function were collected from 339 children annually from kindergarten to second grade. 30059155 2018
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.080 AlteredExpression phenotype BEFREE Children's resting ANS functioning (respiratory sinus arrhythmia; RSA; pre-ejection period; PEP; and heart rate; HR) was collected at 1, 3.5, and 5years of age (N=336) and modeled across time using Hierarchical Linear Modeling. 28238817 2017