PREP, prolyl endopeptidase, 5550

N. diseases: 105; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.050 Biomarker disease BEFREE The enhancement of drug penetration in tumors by TP-pep-targeted nanoparticles may represent an innovative strategy for neuroblastoma. 30294852 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.050 Biomarker disease BEFREE We recently reported that POP inhibition suppressed the growth of human neuroblastoma cells. 24269815 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.050 Biomarker disease BEFREE In this study, we investigated the protective effects of PEA-15 on neuronal damage induced by MPP(+) in neuroblastoma SH-SY5Y and BV2 microglia cells and in a MPTP-induced PD mouse model using cell-permeable PEP-1-PEA-15. 24412329 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.050 AlteredExpression disease BEFREE Here, we report the levels and subcellular distribution of PREP in human neuroblastoma SH-SY5Y cells in proliferating conditions and under differentiation induced by retinoic acid (RA). 21487212 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.050 Biomarker disease LHGDN Here, we demonstrate using biochemical methods of subcellular fractionation, immunocytochemical double-labelling procedures and localization of PEP-enhanced green fluorescent protein fusion proteins that PEP is mainly localized to the perinuclear space, and is associated with the microtubulin cytoskeleton in human neuroblastoma and glioma cell lines. 16092940 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.050 Biomarker disease BEFREE Here, we demonstrate using biochemical methods of subcellular fractionation, immunocytochemical double-labelling procedures and localization of PEP-enhanced green fluorescent protein fusion proteins that PEP is mainly localized to the perinuclear space, and is associated with the microtubulin cytoskeleton in human neuroblastoma and glioma cell lines. 16092940 2005