|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
A recent report detected association between GPR50, an orphan G protein-coupled receptor, and bipolar disorder (BD) in the Scottish population [29].
|
20371266 |
2010 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
A recent report detected association between GPR50, an orphan G protein-coupled receptor, and bipolar disorder (BD) in the Scottish population [29].
|
20371266 |
2010 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective disorder (BPAD) in a large Scottish family.
|
16389273 |
2006 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective disorder (BPAD) in a large Scottish family.
|
16389273 |
2006 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.
|
15452587 |
2005 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
GPR50 is an orphan G protein-coupled receptor (GPCR) located on Xq28, a region previously implicated in multiple genetic studies of bipolar affective disorder (BPAD).
|
15452587 |
2005 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.320 |
Biomarker
|
disease |
PSYGENET |
The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective disorder (BPAD) in a large Scottish family.
|
16389273 |
2006 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective disorder (BPAD) in a large Scottish family.
|
16389273 |
2006 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.
|
15452587 |
2005 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.320 |
Biomarker
|
disease |
BEFREE |
GPR50 is an orphan G protein-coupled receptor (GPCR) located on Xq28, a region previously implicated in multiple genetic studies of bipolar affective disorder (BPAD).
|
15452587 |
2005 |
|
Mood Disorders
|
0.310 |
GeneticVariation
|
group |
BEFREE |
We investigated the relationship of the gene for the X-linked orphan G protein-coupled receptor (GPR50) to childhood-onset mood disorders in a sample of 384 families with 468 affected children and adolescents collected in Hungary.
|
18075476 |
2007 |
|
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
However, cure of MM is still difficult, and several other targets, for example immunoglobulin kappa chain, SLAM Family Member 7 (SLAMF7), or G-protein coupled receptor family C group 5 member D (GPRC5D), are being tested as targets for CAR T cells.
|
31847470 |
2019 |
|
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Additional ADCs and bispecific antibodies targeting BCMA and other surface antigens (eg, CD38, CD46, CD48, FcRH5, and G protein-coupled receptor, class C group 5 member D) are moving forward in phase 1 trials and may provide even more options for MM patients.
|
31808859 |
2019 |
|
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings suggest that GPRC5D is an antigen specific to multiple myeloma and a potential target of TRAB therapy.
|
31270154 |
2019 |
|
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
GPRC5D(109) is specific for GPRC5D and resulted in MM cell line and primary MM cytotoxicity, cytokine release, and in vivo activity comparable to anti-BCMA CAR T cells.
|
30918115 |
2019 |
|
Multiple Myeloma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Highly variable levels of GPRC5D (median, 288; quartiles, 17-928) were detected in patients with MM, whereas only low expression was detected in normal tissues (median, 1; quartiles, 1-23).
|
22591013 |
2012 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
RP11-392P7.6 is antisense to the coding region of cancer-related gene GPRC5D, which has been found recently.
|
28612367 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
RP11-392P7.6 is antisense to the coding region of cancer-related gene GPRC5D, which has been found recently.
|
28612367 |
2017 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Here, we report, for the first time, the association of GPRC5D expression and cancer.
|
22591013 |
2012 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Here, we report, for the first time, the association of GPRC5D expression and cancer.
|
22591013 |
2012 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
|
20818416 |
2011 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
|
20818416 |
2011 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
RAI3 is an orphan G-protein coupled receptor (GPCR) that has been associated with malignancy and may play a role in the proliferation of breast cancer cells.
|
19552806 |
2009 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
RAI3 is an orphan G-protein coupled receptor (GPCR) that has been associated with malignancy and may play a role in the proliferation of breast cancer cells.
|
19552806 |
2009 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
GPRC5A is an orphan G-protein coupled receptor with an intriguing dual behavior, acting as an oncogene in some cancers and as a tumor suppressor in other cancers.
|
27415424 |
2016 |