SOX6, SRY-box transcription factor 6, 55553

N. diseases: 105; N. variants: 46
Disease: Osteoporosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.140 GeneticVariation disease BEFREE SOX6 rs7117858 polymorphism is associated with osteoporosis and obesity-related phenotypes. 30062780 2018
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.140 Biomarker disease BEFREE Given the biological function of SOX6 and the GWAS finding, we considered SOX6 as a new candidate for BMD and osteoporosis. 21625884 2012
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.140 Biomarker disease BEFREE A comprehensive review of these developments revealed that, to date, at least 15 genes (VDR, ESR1, ESR2, LRP5, LRP4, SOST, GRP177, OPG, RANK, RANKL, COLIA1, SPP1, ITGA1, SP7, and SOX6) can be reasonably assigned as confirmed osteoporosis susceptibility genes, whereas, another >30 genes are promising candidate genes. 20101412 2010
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.140 Biomarker disease BEFREE Our findings, together with the prior biological evidence, suggest the SOX6 gene's importance in co-regulation of obesity and osteoporosis. 19714249 2009
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.140 GeneticVariation disease GWASCAT Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males. 19714249 2009