Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Since AMPK is a direct regulator of tau phosphorylation, we hypothesized that strict diet control to achieve euglycaemia affects tau protein phosphorylation through increased AMPK activity in the hippocampus of DM rats.
|
31799531 |
2020 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, we hypothesized that PT may confer protection against myocardial IR injury in diabetes via AMPK activation.
|
29689567 |
2018 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We observed no significant association between AMPK genotype and pancreatic cancer and no genotype interactions with diabetes or smoking.
|
21357378 |
2011 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function.
|
24135141 |
2013 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In humans, AMPK regulates lipid and glucose metabolism and has been implicated in such metabolic disorders as diabetes and obesity and in cardiac abnormalities.
|
12847291 |
2003 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes.
|
22412912 |
2012 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
These results identify the UBE2O/AMPKα2 axis as both a potent regulator of metabolic homeostasis in skeletal muscle and a therapeutic target in the treatment of diabetes and metabolic disorders.
|
31292296 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Novel protective mechanism of reducing renal cell damage in diabetes: Activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA damage.
|
27611085 |
2016 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Specifically, our results show that activation of AMPK increases memory dysfunction in males but is protective in females, suggesting that gender considerations may constitute an important factor in medical intervention of diabetes as well as AD.
|
25190626 |
2015 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, the therapeutic potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such as diabetes, but also obesity, inflammation, and cancer.
|
28622524 |
2017 |
Diabetes Mellitus
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
ALDH2 deficiency potentiates oxidative stress and AMPK phosphorylation induced by diabetes via post-translational regulation of LKB1.
|
27488451 |
2016 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Understanding how ER stress suppresses AMPK activation and increases C/EBPβ expression could lead to a potentially novel pathway for treatment of diabetes.
|
20797423 |
2011 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Inconsistent findings have been reported relating to the role of cardiac AMPK and β-adrenergic signaling in diabetes, and systemic administration of agents targeting these pathways appear to elicit some cardiac benefit, but whether these effects are related to direct cardiac actions is uncertain.
|
29109032 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our results identify the AMPK/mTORC1/Nox4 signaling axis as a molecular switch correlating diabetes and CRC.
|
31661292 |
2019 |