Hyperglycemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Further, lutein and oxidized lutein augmented the AMPK phosphorylation and activation of mitochondrion signaling molecule TFAM (protein expression) and mRNA expression of PGC-1α, TFAM, and nuclear respiratory factor 1 (responsible for mitochondria biogenesis) along with lowered reactive oxygen species in HG compared with control and metformin groups.
|
31529536 |
2019 |
Hyperglycemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Hyperglycemia impaired metformin-induced AMPK<sup>Thr172</sup> activation and enhanced phosphorylation of AMPK at serine-485 (AMPK<sup>Ser485</sup>).
|
31205529 |
2019 |
Hyperglycemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Hepatic FAM3A restoration activates ATP-P2 receptor-Akt and AMPK pathways to attenuate steatosis and hyperglycemia in obese diabetic mice.
|
29221790 |
2018 |
Hyperglycemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Reductions in AMPK activity potentiate the effects of acute OLZ treatment on blood glucose, whereas specifically targeting AMPK β1-containing complexes is sufficient to protect against OLZ-induced hyperglycemia.-Shamshoum, H., Medak, K. D., Townsend, L. K., Ashworth, K. E., Bush, N. D., Hahn, M. K., Kemp, B. E., Wright, D. C. AMPK β1 activation suppresses antipsychotic-induced hyperglycemia in mice.
|
31581839 |
2019 |
Hyperglycemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
AMPK activation stimulates fatty acid oxidation, enhances insulin sensitivity, alleviates hyperglycemia and hyperlipidemia, and inhibits proinflammatory changes.
|
20222801 |
2010 |
Hyperglycemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Here, we report that hyperglycemia inhibits AMPK pathway and subsequently reduces ADR induced DNA damage, resulting in decreased chemotherapeutic sensitivity of Adriamycin (ADR).
|
29941677 |
2018 |
Hyperglycemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Nevertheless, intervention with repeated daily administration of short-acting activation of AMPK was found to mitigate hyperglycemia and hyperinsulinemia in four rodent models of metabolic disease and without the cardiac glycogen accretion noted with sustained pharmacologic AMPK activation.
|
30811418 |
2019 |
Hyperglycemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK.
|
28743390 |
2017 |
Hyperglycemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
The AMPK inhibitor and anti-diabetic drug metformin may counteract everolimus-induced hyperglycemia, as well as enhancing anti-cancer efficacy.
|
28356082 |
2017 |