|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resveratrol and Metformin Recover Prefrontal Cortex AMPK Activation in Diet-Induced Obese Mice but Reduce BDNF and Synaptophysin Protein Content.
|
31450493 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation.
|
31443565 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
As suggested by the molecular docking study, such bioactivity of alisol A may result from its selective binding to the catalytic region of AMPK.Therefore, we believe that Alisol A could serve as a promising agent for treatment of obesity and its related metabolic diseases.
|
31144451 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
EPS improved insulin signal transduction in myotubes from lean but not severely obese subjects and increased AMP accumulation and AMPK Thr<sup>172</sup> phosphorylation, but to a lesser degree in myotubes from the severely obese.
|
30414190 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene silencing study revealed that Med promotes the development of brown- and beige-adipocyte characteristics in C3H10T1/2 mesenchymal stem cells through activation of the AMPK pathway, and our data allow us to propose Med as a candidate for therapeutics against obesity or related metabolic disorders.© 2017 BioFactors, 44(2):168-179, 2018.
|
29064586 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro.
|
29141998 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that metformin improves low-grade inflammation in obesity and modulates macrophage polarization to an anti-inflammatory, M2 phenotype partly via the activation of AMPK.
|
28935544 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we determined the effect of the oral administration of the extract of <i>D. morbifera</i> on obesity and hepatic steatosis in high-fat diet (HFD)-induced obese mice.This study proved that <i>D. morbifera</i> containing HOD, the active substance, can show preventive or therapeutic efficacy on obesity and hepatic steatosis through the targeting LKB1/AMPK axis.
|
29875667 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice.
|
30235452 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aims of the current study were to identify the beneficial effects of crocin on obesity, adipocyte differentiation, and lipolysis and to evaluate the possible role of AMPK.
|
30674760 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
EGCG Reduces Obesity and White Adipose Tissue Gain Partly Through AMPK Activation in Mice.
|
30524290 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, our findings point to hypothalamic AMPK in specific neuronal populations as a potential druggable target for the treatment of obesity and associated metabolic disorders.
|
30104247 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice.
|
28264489 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that zerumbone ameliorated diet-induced obesity and inhibited adipogenesis, and that the underlying mechanisms involved AMPK and the microRNA-146b/SIRT1 pathway.
|
28445161 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This increased cAMP activated AMPK, enhanced oxidative decomposition of lipids, and inhibited de novo synthesis of fatty acids, inhibiting the development and progression of obesity and type 2 diabetes.
|
28811612 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, the therapeutic potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such as diabetes, but also obesity, inflammation, and cancer.
|
28622524 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that greater infant adiposity is associated with suppressed AMPK activity and reduced lipid oxidation in MSCs from infants born to mothers with obesity and may be an important, early marker of underlying obesity risk.
|
29107296 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
AMPK links inflammation, metabolism and T2D, with roles to play in all and is influenced negatively by obesity.
|
27128935 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrate that vitamin D treatments decreased insulin resistance, reduced leptin, and increased adiponectin signaling and also regulated the LKB1/AMPK pathway contributing to an overall decrease in local estrogen synthesis in the obese mice.
|
26817629 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impaired AMPK is associated with a wide spectrum of clinical and pathological conditions, ranging from obesity, altered responses to exercise or metabolic syndrome, to inflammation, disturbed mitochondrial biogenesis and defective response to energy stress.
|
25779083 |
2015 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity in WT mice fed a HFD associated with elevated serum IL-6 levels, fatty liver, upregulation of carnitine palmitoyltransferase 1 (CPT1) and signal transducer and activator of transcription-3 (STAT3), increased AMP kinase phosphorylation (p-AMPK), and downregulation of the hepatic lipogenic enzymes fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1).
|
26035386 |
2015 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, an α-MG supplement up-regulated hepatic AMPK, SirT1, and PPARγ levels compared with the high-fat diet states, suggesting that α-MG regulates hepatic steatosis and obesity through the SirT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice.
|
26368128 |
2015 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These novel findings suggest that dietary MUFA can attenuate IL-1β-mediated insulin resistance and adipose dysfunction despite obesity via the preservation of AMPK activity.
|
25626736 |
2015 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Collectively, ECPE supplement might have potential antiobesity effects via regulation of AMPK and SIRT1 in HFD-induced obesity.
|
25479240 |
2015 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Indicative of a lipotoxic environment, increased placental lipid and CIDEA protein were associated with decreased AMPK and increased activation of NF-κB (p65) in placenta from obese women.
|
24484739 |
2014 |