Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014057
Disease: Japanese Encephalitis
Japanese Encephalitis
0.010 Biomarker disease BEFREE Japanese encephalitis virus (JEV) is classified into 5 genotypes (GI, GII, GIII, GIV, and GV), and the GI and GIII strains are the most widely distributed in JE endemic areas. 30381682 2019
CUI: C0019159
Disease: Hepatitis A
Hepatitis A
0.010 GeneticVariation disease BEFREE Hepatitis A virus (HAV), genogroup GI, GII, and GIV norovirus (NoV), enterovirus (EV), rotavirus (RoV), hepatitis E virus (HEV), adenovirus (AdV), and bocavirus (BoV) were detected by nested (RT) PCR, real-time PCR, and sequence analysis. 30639406 2019
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases
0.010 Biomarker group BEFREE The unique presence of serpin A3-7, coiled-coil domain containing 88A and inhibin/activin β A chain in HR-EXO, indicates potential biomarkers for cows at-risk for metabolic diseases. 31554846 2019
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.010 GeneticVariation disease BEFREE The aim of this prospective registry-based population study was to investigate the association between QoL 3 years after surgery for rectal cancer and intrusive thoughts and to assess the association with the type of surgery (i.e., APE or ELAPE) in a population-based national cohort. 29665309 2018
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases
0.010 Biomarker group BEFREE However, the role of Ang II in the interaction between apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) and sphingosine-1-phosphate (S1P) signals in relation to vascular disorders remains to be clarified. 29609002 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.010 Biomarker disease BEFREE Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer. 29456687 2018
CUI: C0558066
Disease: Intrusive thoughts
Intrusive thoughts
0.010 Biomarker disease BEFREE Association between operative technique and intrusive thoughts on health-related Quality of Life 3 years after APE/ELAPE for rectal cancer: results from a national Swedish cohort with comparison with normative Swedish data. 29665309 2018
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.010 Biomarker disease BEFREE Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer. 29456687 2018
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.010 Biomarker disease BEFREE Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer. 29456687 2018
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.010 Biomarker disease BEFREE Clinico-pathological analysis reveals 83% of high-grade astrocytoma (GIII + GIV) and 30% of low-grade (GII) tissue samples which were detected with pDok2 expression. 27975172 2018
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.010 Biomarker group BEFREE Finally, animal experiments were performed to demonstrate the effect of CCDC88A silencing on the radiosensitivity of hepatoma in vivo. 28810896 2017
CUI: C0039494
Disease: Temporomandibular Joint Disorders
Temporomandibular Joint Disorders
0.010 Biomarker group BEFREE Forty five children (mean age 8.8 years; 22 boys and 23 girls) were examined on the basis of the RDC/TMD and the Faces Pain Scale-Revised (FPS-R) was used to determine the level of severity of the signs and symptoms of TMD, resulting in four groups: GI - without TMD (n=10); GII - with mild TMD (n=18), GIII: with moderate TMD (n=12) and GIV: with severe TMD (n=5). 29053659 2017
CUI: C0042900
Disease: Vitiligo
Vitiligo
0.010 Biomarker disease BEFREE The inflammatory response in vitiligo is thought to be mediated by polymorphism in genes such as FOXP3, ACE, APE, GSTP1, TLR, SOD, CTLA-4, TAP/LMP gene cluster, etc. 29199612 2017
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
0.010 Biomarker disease BEFREE The inflammatory response in vitiligo is thought to be mediated by polymorphism in genes such as FOXP3, ACE, APE, GSTP1, TLR, SOD, CTLA-4, TAP/LMP gene cluster, etc. 29199612 2017
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.010 GeneticVariation group BEFREE The purpose of this study was to explore whether an APE e-learning supplement would have an impact on the level of self-efficacy and content knowledge of pre-service teachers related to including students with intellectual disabilities. 28800425 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.010 Biomarker disease BEFREE Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers. 27440794 2016
CUI: C4552072
Disease: X-linked infantile spasms
X-linked infantile spasms
0.010 Biomarker disease BEFREE Atypical cases are often known as PEHO-like, and there is an overlap with 'early infantile epileptic encephalopathy'. 26917597 2016
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.010 Biomarker disease BEFREE Therefore, our finding highlights a novel aspect of STAT3/GIV pathway in the IL-17 promotes tumor angiogenesis of NSCLC. 26524953 2015
CUI: C0267446
Disease: Acute gastroenteritis
Acute gastroenteritis
0.010 Biomarker disease BEFREE Noroviruses are important causes of acute gastroenteritis and are classified into six genogroups with GI, GII and GIV containing human pathogens. 26248055 2015
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.010 Biomarker phenotype BEFREE Therefore, our finding highlights a novel aspect of STAT3/GIV pathway in the IL-17 promotes tumor angiogenesis of NSCLC. 26524953 2015
CUI: C0009765
Disease: Conjunctivitis, Acute Hemorrhagic
Conjunctivitis, Acute Hemorrhagic
0.010 GeneticVariation disease BEFREE Interestingly, our isolates shared greatest homology with the GIV-C4 strains, not with the isolates that were responsible for the nationwide acute hemorrhagic conjunctivitis epidemic in China in 2007. 24475191 2014
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.010 Biomarker disease BEFREE We also provide evidence that GIV may serve as a biomarker for progression of fibrosis after liver injury and a therapeutic target for arresting and/or reversing HSC activation during liver fibrosis. 25043713 2014
Secondary malignant neoplasm of liver
0.010 AlteredExpression disease BEFREE After analyzing survival rates, cases with highly expressed Girdin protein were shown to attain a significantly higher rate of liver metastasis and poorer postoperative, disease-specific survival than those with no or low expressed Girdin protein (P = 0.001). 22714912 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 AlteredExpression disease BEFREE Immunohistochemical analysis of breast carcinomas showed significant correlation between STAT3 activation and elevated GIV expression. 23066027 2012
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.010 AlteredExpression group BEFREE Here we report the discovery that GIV is a direct target of the transcription factor signal transducer and activator of transcription-3 (STAT3), which is commonly known as a central regulator of tumor metastasis. 23066027 2012