VPS35, VPS35 retromer complex component, 55737

N. diseases: 66; N. variants: 6
Disease: PARKINSON DISEASE 17 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 GeneticVariation disease UNIPROT VPS35 mutations in Parkinson disease. 21763482 2011
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 GeneticVariation disease UNIPROT Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. 24819384 2014
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 GeneticVariation disease UNIPROT RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. 23395371 2013
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 GeneticVariation disease UNIPROT A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. 21763483 2011
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 GeneticVariation disease UNIPROT Identification of VPS35 mutations replicated in French families with Parkinson disease. 22517097 2012
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 GeneticVariation disease UNIPROT Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation. 24980502 2014
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 Biomarker disease MGD VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease. 26203154 2015
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 Biomarker disease CTD_human
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 Biomarker disease GENOMICS_ENGLAND Frequency of the ASP620ASN mutation in VPS35 and Arg1205His mutation in EIF4G1 in familial Parkinson's disease from South Italy. 24854799 2014
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 Biomarker disease GENOMICS_ENGLAND Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease. 23408866 2013
CUI: C3280133
Disease: PARKINSON DISEASE 17
PARKINSON DISEASE 17 		0.900 CausalMutation disease CLINVAR