|
Mammary Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Compared with MENA, higher levels of the prometastatic MENA(INV) isoform associate with α5, which enables 3-D haptotaxis of tumor cells toward the high FN concentrations typically present in perivascular space and in the periphery of breast tumor tissue.
|
26811325 |
2016 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression of ENAH isoform 11a has been shown to be elevated in breast cancers that express HER2.
|
26149387 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT)-related genes and a switch to mesenchymal splice variants of several genes, including ENAH (MENA).
|
25670169 |
2015 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity.
|
25556597 |
2015 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
A typical sequencing study can easily generate hundreds of gigabytes of FASTQ files, while public archives such as ENA and NCBI and large international collaborations such as the Cancer Genome Atlas can accumulate many terabytes of data in this format.
|
24950811 |
2014 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
A typical sequencing study can easily generate hundreds of gigabytes of FASTQ files, while public archives such as ENA and NCBI and large international collaborations such as the Cancer Genome Atlas can accumulate many terabytes of data in this format.
|
24950811 |
2014 |
|
Mammary Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors.
|
23129656 |
2012 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The candidate genes located at amplified regions of chromosomes or low-level gain regions such as PLA2G5 (1p36-p34), COL11A1 (1p21), KCNK2 (1q41), S100A3 (1q21), ENAH (1q42.12), RGS1 (1q31), KCNH1 (1q32-q41), INSIG2 (2q14.1), FGF12 (3q28), TRIO (5p15.2), RNASEN (5p15.2), FGF10 (5p13-p12), EDN1(6p24.1-p22.3), SULF1 (8q13.2-13.3), TLR4 (9q32-q33), TNC (9q33), NTRK2 (9q22.1), CD44 (11p13), NCAM1 (11q23.1), TRIM29 (11q22-q23), PAK1 (11q13-q14) and RAB27A (15q15-q21.1), are found to be associated with cellular migration and proliferation, tumor cell metastasis and invasion, anchorage independent growth and inhibition of apoptosis.
|
20083228 |
2010 |
|
Mammary Neoplasms
|
0.030 |
AlteredExpression
|
group |
LHGDN |
The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors.
|
16533770 |
2006 |
|
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review.
|
31612830 |
2020 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
ENAH expression markedly associated with tumor size (<i>P</i> < 0.001), T stage (<i>P</i> < 0.001), N stage (<i>P</i> = 0.001), TNM stage (<i>P</i> < 0.001) and prognosis (<i>P</i> < 0.001).
|
29069803 |
2017 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our research suggests that ENAH might play promoting functions in carcinogenesis and progression of gastric cancer, and may serve as a valuable prognostic marker for primary gastric adenocarcinoma patients.
|
29069803 |
2017 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A high MENA protein level was associated with high mRNA levels of MENA, CD133, cytokeratin 19 (CK19), and epithelial cell adhesion molecule (EpCAM) in human HCC tissues.
|
28781954 |
2017 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MENA(INV) and FN levels were correlated in two breast cancer cohorts, and high levels of MENA(INV) were significantly associated with increased tumor recurrence as well as decreased patient survival.
|
26811325 |
2016 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT)-related genes and a switch to mesenchymal splice variants of several genes, including ENAH (MENA).
|
25670169 |
2015 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of Mena protein in 81 specimens of HCC tissues was determined by immunohistochemistry.
|
24683008 |
2014 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Few recent studies have revealed that Mena protein could play a role in breast or pancreatic carcinogenesis.
|
23956979 |
2013 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The candidate genes located at amplified regions of chromosomes or low-level gain regions such as PLA2G5 (1p36-p34), COL11A1 (1p21), KCNK2 (1q41), S100A3 (1q21), ENAH (1q42.12), RGS1 (1q31), KCNH1 (1q32-q41), INSIG2 (2q14.1), FGF12 (3q28), TRIO (5p15.2), RNASEN (5p15.2), FGF10 (5p13-p12), EDN1(6p24.1-p22.3), SULF1 (8q13.2-13.3), TLR4 (9q32-q33), TNC (9q33), NTRK2 (9q22.1), CD44 (11p13), NCAM1 (11q23.1), TRIM29 (11q22-q23), PAK1 (11q13-q14) and RAB27A (15q15-q21.1), are found to be associated with cellular migration and proliferation, tumor cell metastasis and invasion, anchorage independent growth and inhibition of apoptosis.
|
20083228 |
2010 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We also performed immunohistochemical analysis of the expression of hMena protein in 50 cases of paraffin-embedded archival colorectal tissues, and found that an elevated hMena expression is correlated to the cases with advanced TNM stages of colorectal carcinomas (P<0.001).
|
19082477 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review.
|
31612830 |
2020 |
|
Cardiovascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In this exploratory analysis, the first of its kind in the MENA region, vitamin D deficiency was associated with abnormal lipid markers, non-lipid markers of CVD, male gender, lower eGFR, and a surrogate variable for CVD.
|
30097651 |
2019 |
|
Hypercholesterolemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Subjects from the MENA cohort (n=474) were categorized according to age (<45 vs 45>) and the presence of metabolic alterations: increased waist circumference, hypercholesterolemia, insulin resistance, and metabolic syndrome.
|
30926763 |
2019 |
|
Influenza
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Meeting participants concluded that influenza remains a significant threat especially in high-risk groups (children under-5, elderly, pregnant women and immunosuppressed individuals) in the MENA-ISN region.
|
30801995 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the MENA region, only one study targets the frequency of genetic modifications in AML, reporting a higher occurrence of acute promyelocytic leukemia in Lebanon.
|
30701458 |
2019 |
|
Mixed Connective Tissue Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-dsDNA antibodies were higher in SLE and ENA showed the highest titers in MCTD.
|
30807792 |
2019 |