|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The top psychosis-associated, differentially methylated region, significantly hypomethylated in affected twins, was located in the promoter of ST6GALNAC1 overlapping a previously reported rare genomic duplication observed in SZ.
|
21908516 |
2011 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The top psychosis-associated, differentially methylated region, significantly hypomethylated in affected twins, was located in the promoter of ST6GALNAC1 overlapping a previously reported rare genomic duplication observed in SZ.
|
21908516 |
2011 |
|
Nonorganic psychosis
|
0.300 |
Biomarker
|
disease |
PSYGENET |
The top psychosis-associated, differentially methylated region, significantly hypomethylated in affected twins, was located in the promoter of ST6GALNAC1 overlapping a previously reported rare genomic duplication observed in SZ.
|
21908516 |
2011 |
|
Malignant neoplasm of urinary bladder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The sialyl-Tn (sTn) antigen is an <i>O</i>-linked carbohydrate chain aberrantly expressed in bladder cancer (BC), whose biosynthesis is mainly controlled by the sialyltransferase ST6GALNAC1.
|
28903359 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability.
|
23567325 |
2013 |
|
Bladder Neoplasm
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The sialyl-Tn (sTn) antigen is an <i>O</i>-linked carbohydrate chain aberrantly expressed in bladder cancer (BC), whose biosynthesis is mainly controlled by the sialyltransferase ST6GALNAC1.
|
28903359 |
2017 |
|
Bladder Neoplasm
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability.
|
23567325 |
2013 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In a subsequent replication study for five genes, four of the five genes were validated; FAM124B and ST6GALNAC1 were significantly hypermethylated, and NAV1 and PER1 were significantly hypomethylated in ER+/PR+ breast cancers (P < 0.05).
|
20724461 |
2010 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
STn-positive (STn<sup>+</sup>) breast cancer cells were generated by stable transfection of an expression vector encoding ST6GaLNAc I into the breast cancer cell line MDA-MB-231.
|
31595388 |
2019 |
|
Carcinoma of bladder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability.
|
23567325 |
2013 |
|
Carcinoma of bladder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The sialyl-Tn (sTn) antigen is an <i>O</i>-linked carbohydrate chain aberrantly expressed in bladder cancer (BC), whose biosynthesis is mainly controlled by the sialyltransferase ST6GALNAC1.
|
28903359 |
2017 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Crosstalk between colon cells and macrophages increases ST6GALNAC1 and MUC1-sTn expression in ulcerative colitis and colitis-associated colon cancer.
|
31831633 |
2020 |
|
Malignant neoplasm of endometrium
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene. sTn neo- or over-expression occurs in many types of epithelial cancer including gastric, colon, breast, lung, oesophageal, prostate and endometrial cancer. sTn is believed to be carried by a variety of glycoproteins and may influence protein function and be involved in tumour development.
|
26927062 |
2016 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunostaining of UC and CACC tissue samples confirmed the elevated number of M2-like macrophages as well as high expression of ST6GALNAC1 and the altered MUC1-sTn glycoform on colon cells.
|
31831633 |
2020 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway.
|
29348846 |
2017 |
|
Endometriosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ST6GALNAC1 gene expression was significantly lower in endometriotic lesions compared to that in eutopic endometrium of endometriosis-affected patients and healthy endometrium (16-fold for both; P < 0.01).
|
30753458 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, intraperitoneal administration of ST6GalNAc I siRNA- liposome significantly inhibited peritoneal dissemination and prolonged the survival of xenograft model mice with peritoneal dissemination of gastric cancer.
|
25532910 |
2016 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study suggests Siat7A could be a valuable target for developing treatments for MI patients.
|
25860962 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results indicated that ST6GALNAC1 was downregulated in sporadic ESCC via hyper-methylation and LOH, and it may be a candidate responsible gene for ESCC.
|
28035351 |
2017 |
|
Ventricular hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Delivery of adeno-associated viral (AAV9) bearing shRNA against rat Siat7A into the left ventricular wall inhibited ventricular hypertrophy.
|
30854566 |
2020 |
|
Endometrial Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene. sTn neo- or over-expression occurs in many types of epithelial cancer including gastric, colon, breast, lung, oesophageal, prostate and endometrial cancer. sTn is believed to be carried by a variety of glycoproteins and may influence protein function and be involved in tumour development.
|
26927062 |
2016 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
STn-positive (STn<sup>+</sup>) breast cancer cells were generated by stable transfection of an expression vector encoding ST6GaLNAc I into the breast cancer cell line MDA-MB-231.
|
31595388 |
2019 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Crosstalk between colon cells and macrophages increases ST6GALNAC1 and MUC1-sTn expression in ulcerative colitis and colitis-associated colon cancer.
|
31831633 |
2020 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, intraperitoneal administration of ST6GalNAc I siRNA- liposome significantly inhibited peritoneal dissemination and prolonged the survival of xenograft model mice with peritoneal dissemination of gastric cancer.
|
25532910 |
2016 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
This present study aims to investigate how ST6GALNAC1 affects ovarian cancer stem cells (OCSCs).
|
30996686 |
2019 |