Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Offspring from VPA group were divided into ASD group and ASD + rapamycin (ASD + RAPA) group.
|
28360521 |
2017 |
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Breast Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
|
19075277 |
2009 |
Breast Carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.
|
17015480 |
2006 |
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrated that patches loaded with 5-FU-RAPA-PLA-NP significantly inhibited the growth of colon cancer in vitro and in vivo.
|
31181443 |
2019 |
Depressed mood
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Both groups exhibited significant improvements in the RAPA measures of physical activity and depression.
|
31126543 |
2019 |
Depressive disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both groups exhibited significant improvements in the RAPA measures of physical activity and depression.
|
31126543 |
2019 |
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, the authors of the present study hypothesize that TRERF1 aberrations may be involved in the development of endometriosis.
|
29393434 |
2018 |
Endometriosis of ovary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To the best of our knowledge, the present study was the first to identify 2 novel, potentially 'disease‑causing' TRERF1 somatic mutations in the endometriotic lesions in 2 out of 92 patients with ovarian endometriosis; therefore, TRERF1 mutations may be involved in the pathogenesis of ovarian endometriosis.
|
29393434 |
2018 |
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Incontinentia Pigmenti Achromians
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of mTOR and S6K was significantly increased in the CTX + IPA + IL-12 group compared with the control, IPA (P = 0.01; P= 0.001), and CTX + IPA (P = 0.034; P= 0.032) groups, but significantly decreased in the CTX + IPA + RAPA group (P < 0.001).
|
28485322 |
2017 |
Limb ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using murine limb ischemia as a tumor-free assay system, we demonstrated that p70S6K inhibitor rapamycin (RAPA) targets mesenchymal cells to shut down the sustained expression of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), via silencing of the PDGFRalpha-p70S6K pathway.
|
15059936 |
2004 |
Lymphocyte Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
|
22286170 |
2012 |
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
BEFREE |
TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.
|
17015480 |
2006 |
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
CTD_human |
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
|
19075277 |
2009 |
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrated that patches loaded with 5-FU-RAPA-PLA-NP significantly inhibited the growth of colon cancer in vitro and in vivo.
|
31181443 |
2019 |
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
|
19075277 |
2009 |
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
mRNA levels of 10 BCAR genes (AKT1, AKT2, BCAR1, BCAR3, EGFR, ERBB2, GRB7, SRC, TLE3, and TRERF1) were measured in estrogen receptor-positive breast tumors using quantitative reverse-transcriptase polymerase chain reaction.
|
19075277 |
2009 |
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
LHGDN |
TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.
|
17015480 |
2006 |
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
mRNA levels of 10 BCAR genes (AKT1, AKT2, BCAR1, BCAR3, EGFR, ERBB2, GRB7, SRC, TLE3, and TRERF1) were measured in estrogen receptor-positive breast tumors using quantitative reverse-transcriptase polymerase chain reaction.
|
19075277 |
2009 |
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
|
19075277 |
2009 |
Mental Depression
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both groups exhibited significant improvements in the RAPA measures of physical activity and depression.
|
31126543 |
2019 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Because RAPA showed only a minimal effect to hypoxia-related expression of VEGF in culture, these results suggest that RAPA targets the host-vasculature rather than tumor itself in vivo.
|
15059936 |
2004 |
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
HL-7702 cells and SK-HEP-1 cells were cultured in vitro as NAFLD cell models and treated with RAPA to induce autophagy.
|
30573200 |
2018 |