PRKCE, protein kinase C epsilon, 5581

N. diseases: 112; N. variants: 51
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker disease CTD_human Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids. 7705931 1995
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation disease UNIPROT
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.320 Biomarker phenotype BEFREE Protein kinase C ε (PKCε) AS-ODN also prevented LDM-induced hyperalgesia and priming, whereas analgesia and priming induced by HDM were unaffected. 31209174 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.320 Biomarker phenotype CTD_human While PKCepsilon activation can induce acute hyperalgesia in the IB4(+) population, it fails to induce priming. 20457222 2010
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.320 Biomarker phenotype LHGDN Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. 16793902 2006
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.320 Biomarker phenotype CTD_human Injection of 5- and 12-lipoxygenase produced hyperalgesia that was not antagonized by inhibitors of PKA, PKCepsilon or MAPK.These findings suggest that: (1). lipoxygenase products of arachidonic acid function as second messengers in the peripheral hyperalgesia induced by agents that act directly on primary afferent nociceptors (epinephrine and prostaglandin E(2)), (2). products of the 5-lipoxygenase and 12-lipoxygenase pathway are involved in this function, and (3). these lipoxygenase products contribute to hyperalgesia at or downstream of protein kinase A and PKCepsilon. 12582831 2003
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.320 Biomarker phenotype CTD_human Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat. 11738263 2001
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.310 Biomarker phenotype BEFREE Furthermore, linear analysis results showed that the densities of p-PKCε and Bcl-<sub>XL</sub> had a reverse linear relationship with the degrees of thermal hyperalgesia and mechanical allodynia. 30679921 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.310 Biomarker phenotype BEFREE Furthermore, linear analysis results showed that the densities of p-PKCε and Bcl-<sub>XL</sub> had a reverse linear relationship with the degrees of thermal hyperalgesia and mechanical allodynia. 30679921 2019
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.310 Biomarker disease CTD_human Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. 29341352 2018
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.310 AlteredExpression disease BEFREE NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39). 23931760 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.310 AlteredExpression disease BEFREE We therefore studied platelet PKCε expression from 24 patients with myocardial infarction, 24 patients with stable coronary artery disease and 24 healthy subjects. 23071564 2012
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.310 Biomarker phenotype CTD_human Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. 20457222 2010
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.310 Biomarker phenotype CTD_human Thus, while PKCepsilon is present in most dorsal root ganglion neurons, where it can contribute to acute mechanical hyperalgesia, priming is restricted to IB4(+)-nociceptors, including those that are TrkA(+). 20457222 2010
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.310 Therapeutic disease CTD_human Attenuated cardioprotection by ischemic preconditioning in coronary stenosed heart and its restoration by carvedilol. 16782078 2006
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.310 Biomarker phenotype CTD_human Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat. 12582831 2003
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.310 Biomarker phenotype CTD_human We evaluated the role of lipoxygenase products of arachidonic acid metabolism in mechanical hyperalgesia induced by epinephrine, an agent that directly sensitizes nociceptors to produce mechanical hyperalgesia via three second messenger signaling pathways, protein kinase A (PKA), protein kinase C epsilon (PKCepsilon), and mitogen activated protein kinase (MAPK). 12582831 2003
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal
0.310 Biomarker phenotype CTD_human Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat. 11738263 2001
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.310 Biomarker phenotype CTD_human Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat. 11738263 2001
CUI: C3241937
Disease: Nonalcoholic Steatohepatitis
Nonalcoholic Steatohepatitis
0.300 Biomarker disease CTD_human Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. 29341352 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker disease CTD_human Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats. 20665664 2010
CUI: C0013146
Disease: Drug abuse
Drug abuse
0.300 Biomarker group CTD_human Genome wide association for addiction: replicated results and comparisons of two analytic approaches. 20098672 2010
CUI: C0013170
Disease: Drug habituation
Drug habituation
0.300 Biomarker phenotype CTD_human Genome wide association for addiction: replicated results and comparisons of two analytic approaches. 20098672 2010
CUI: C0013222
Disease: Drug Use Disorders
Drug Use Disorders
0.300 Biomarker group CTD_human Genome wide association for addiction: replicated results and comparisons of two analytic approaches. 20098672 2010
CUI: C0017667
Disease: Nodular glomerulosclerosis
Nodular glomerulosclerosis
0.300 Biomarker disease CTD_human Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats. 20665664 2010