PRKD1, protein kinase D1, 5587

N. diseases: 171; N. variants: 19
Disease: Pancreatic carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 AlteredExpression disease BEFREE Herein, we report the significance of PKD1 expression in glucose metabolism resulting in pancreatic cancer (PanCa) progression and chemo-resistance. 31819177 2020
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker disease BEFREE These newly retrieved hits were docked against our PKD1 protein model, and those displaying essential interactions are reported herein as new hits, which could serve as new leads for cancer research, especially pancreatic cancer. 29058231 2018
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker disease BEFREE Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells. 28360038 2017
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker disease BEFREE In this mini-review, we highlight the mechanisms of how PKD1 is activated in response to oxidative stress, so far known downstream effectors, as well as the importance of PKD1-initiated signaling for development and progression of pancreatic cancer. 28361035 2017
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker disease BEFREE The PRKD1 promoter is a target of the KRas-NF-κB pathway in pancreatic cancer. 27649783 2016