|
Bullous keratopathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Pseudophakic/aphakic bullous keratopathy (PBK/ABK) human corneas accumulate an extracellular matrix glycoprotein tenascin-C (TN-C), an important modulator of cell adhesion and migration.
|
9603390 |
1998 |
|
Bullous keratopathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We previously found an abnormal deposition of an extracellular matrix glycoprotein, tenascin-C (TN-C), in human corneas with pseudophakic/aphakic bullous keratopathy (PBK/ABK).
|
11668187 |
2001 |
|
Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells.
|
11783945 |
2003 |
|
Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
While PBK/TOPK mRNA was not detectable in normal peripheral blood cells and was weakly expressed in hyperplastic tonsillar B-cells, significantly higher levels of mRNA were detected in 8 Burkitt's lymphoma cell lines, 10 other neoplastic cell lines, and 2 clinical samples-one derived from a patient with ALL and a second derived from a patient with relapsed myeloma.
|
11783945 |
2003 |
|
leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine whether PBK/TOPK is upregulated in other mitotically active neoplastic cell lines and tissues, Northern analysis was performed on a panel of malignant cell lines and on clinical samples from patients with leukemia or lymphoma.
|
11783945 |
2003 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
To determine whether PBK/TOPK is upregulated in other mitotically active neoplastic cell lines and tissues, Northern analysis was performed on a panel of malignant cell lines and on clinical samples from patients with leukemia or lymphoma.
|
11783945 |
2003 |
|
Multiple Myeloma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
While PBK/TOPK mRNA was not detectable in normal peripheral blood cells and was weakly expressed in hyperplastic tonsillar B-cells, significantly higher levels of mRNA were detected in 8 Burkitt's lymphoma cell lines, 10 other neoplastic cell lines, and 2 clinical samples-one derived from a patient with ALL and a second derived from a patient with relapsed myeloma.
|
11783945 |
2003 |
|
Adult Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells.
|
11783945 |
2003 |
|
Childhood Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells.
|
11783945 |
2003 |
|
Adult Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine whether PBK/TOPK is upregulated in other mitotically active neoplastic cell lines and tissues, Northern analysis was performed on a panel of malignant cell lines and on clinical samples from patients with leukemia or lymphoma.
|
11783945 |
2003 |
|
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine whether PBK/TOPK is upregulated in other mitotically active neoplastic cell lines and tissues, Northern analysis was performed on a panel of malignant cell lines and on clinical samples from patients with leukemia or lymphoma.
|
11783945 |
2003 |
|
Childhood Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine whether PBK/TOPK is upregulated in other mitotically active neoplastic cell lines and tissues, Northern analysis was performed on a panel of malignant cell lines and on clinical samples from patients with leukemia or lymphoma.
|
11783945 |
2003 |
|
Noninfiltrating Intraductal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among this set, the mRNA for angio-associated migratory cell protein and a serine threonine protein kinase, nuclear Dbf2 related, were consistently higher in DCIS(necrosis+) and were also found to be overexpressed in the T47D breast cancer cell line subjected to hypoxia.
|
12473591 |
2002 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Previous work has shown up-regulated expression of PBK/TOPK mRNA in a variety of tumor cell lines and fetal tissues, suggesting a role for this kinase in malignant cell proliferation.
|
14757441 |
2004 |
|
Plasmacytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this paper, PBK/TOPK protein expression was examined in a variety of primary hematologic neoplasms: PBK/TOPK was readily detected in 9 of 12 AML samples (75%), in 3 of 3 ALL samples, and in 1 sample each of a plasmacytoma and blastic type mantle cell lymphoma where it was strongly expressed.
|
14757441 |
2004 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this paper, PBK/TOPK protein expression was examined in a variety of primary hematologic neoplasms: PBK/TOPK was readily detected in 9 of 12 AML samples (75%), in 3 of 3 ALL samples, and in 1 sample each of a plasmacytoma and blastic type mantle cell lymphoma where it was strongly expressed.
|
14757441 |
2004 |
|
Hematologic Neoplasms
|
0.010 |
PosttranslationalModification
|
group |
LHGDN |
These data show that PBK/TOPK protein is up-regulated in a variety of hematologic malignancies and may be involved in leukemic cell growth.
|
14757441 |
2004 |
|
Hematologic Neoplasms
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
These data show that PBK/TOPK protein is up-regulated in a variety of hematologic malignancies and may be involved in leukemic cell growth.
|
14757441 |
2004 |
|
Mantle cell lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this paper, PBK/TOPK protein expression was examined in a variety of primary hematologic neoplasms: PBK/TOPK was readily detected in 9 of 12 AML samples (75%), in 3 of 3 ALL samples, and in 1 sample each of a plasmacytoma and blastic type mantle cell lymphoma where it was strongly expressed.
|
14757441 |
2004 |
|
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
Because PBK/TOPK is the cancer/testis antigen and its kinase function is likely to be related to its oncogenic activity, we suggest PBK/TOPK to be a promising molecular target for breast cancer therapy.
|
16982762 |
2006 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Because PBK/TOPK is the cancer/testis antigen and its kinase function is likely to be related to its oncogenic activity, we suggest PBK/TOPK to be a promising molecular target for breast cancer therapy.
|
16982762 |
2006 |
|
Colorectal Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.
|
17631144 |
2007 |
|
Pneumonia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two lead vaccine candidates, protein required for cell wall separation of group B streptococcus (PcsB) and serine/threonine protein kinase (StkP), were found to be exceptionally conserved among clinical isolates (>99.5% identity) and cross-protective against four different serotypes in lethal sepsis and pneumonia models, and have important nonredundant functions in bacterial multiplication based on gene deletion studies.
|
18166586 |
2008 |
|
Septicemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two lead vaccine candidates, protein required for cell wall separation of group B streptococcus (PcsB) and serine/threonine protein kinase (StkP), were found to be exceptionally conserved among clinical isolates (>99.5% identity) and cross-protective against four different serotypes in lethal sepsis and pneumonia models, and have important nonredundant functions in bacterial multiplication based on gene deletion studies.
|
18166586 |
2008 |
|
Sepsis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two lead vaccine candidates, protein required for cell wall separation of group B streptococcus (PcsB) and serine/threonine protein kinase (StkP), were found to be exceptionally conserved among clinical isolates (>99.5% identity) and cross-protective against four different serotypes in lethal sepsis and pneumonia models, and have important nonredundant functions in bacterial multiplication based on gene deletion studies.
|
18166586 |
2008 |