PBK, PDZ binding kinase, 55872

N. diseases: 121; N. variants: 2
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 AlteredExpression disease BEFREE Thus, these findings suggest that SKLB-C05 is a specific TOPK inhibitor with potent anti-CRC oncogenic activity in vitro and in vivo. 30590102 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 Biomarker disease BEFREE We investigated the impact of PBK/TOPK on the clinical outcome of colorectal cancer patients to further identify its role in colorectal cancer. 30286126 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 Biomarker disease BEFREE The purpose of this study was to investigate the role of T-LAK cell-originated protein kinase (TOPK) in the promotion of colorectal cancer metastasis. 28412249 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 Biomarker disease BEFREE Our findings therefore show that HI-TOPK-032 is a specific inhibitor of TOPK both in vitro and in vivo that may be further developed as a potential therapeutic against colorectal cancer. 22523035 2012