|
Retinal Detachment
|
0.500 |
Biomarker
|
disease |
CTD_human |
The homozygous Prkcqrpea1 and the null Prkcqtm1Litt mutants are reliable novel mouse models of RD and can also be used to study the effects of the disruption of PRKCQ (PKCθ) signaling in RPE cells.
|
26978024 |
2016 |
|
Retinal Detachment
|
0.500 |
Biomarker
|
disease |
MGD |
|
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Rheumatoid Arthritis
|
0.340 |
Biomarker
|
disease |
BEFREE |
Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection and rheumatoid arthritis.
|
30704835 |
2019 |
|
Rheumatoid Arthritis
|
0.340 |
Biomarker
|
disease |
BEFREE |
Confocal microscopy and flow cytometry showed that GLK colocalized and coexisted with phosphorylated PKCθ in T cells from RA patients.
|
23817999 |
2013 |
|
Rheumatoid Arthritis
|
0.340 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.340 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.340 |
Biomarker
|
disease |
BEFREE |
In a meta-analysis of Dutch and UK data sets, shared association with six loci (TNFAIP3, IL2/IL21, SH2B3, LPP, MMEL1/TNFRSF14 and PFKFB3/PRKCQ) was observed in both RA and CD cohorts.
|
19648290 |
2009 |
|
Rheumatoid Arthritis
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
The combined dataset also provides definitive support for associations at both CTLA4 (rs231735; OR = 0.85; P = 6.25 x 10(-9)) and BLK (rs2736340; OR = 1.19; P = 5.69 x 10(-9)). c-Rel is an NF-kappaB family member with distinct functional properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.
|
19503088 |
2009 |
|
Rheumatoid Arthritis
|
0.340 |
Biomarker
|
disease |
CTD_human |
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|
18794853 |
2008 |
|
Retinal Pigment Epithelial Detachment
|
0.300 |
Biomarker
|
disease |
CTD_human |
Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, θ.
|
26978024 |
2016 |
|
Lymphoma, T-Cell, Cutaneous
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic landscape of cutaneous T cell lymphoma.
|
26192916 |
2015 |
|
Granulomatous Slack Skin
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic landscape of cutaneous T cell lymphoma.
|
26192916 |
2015 |
|
Diabetes, Autoimmune
|
0.300 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Brittle diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Diabetes Mellitus, Ketosis-Prone
|
0.300 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Diabetes Mellitus, Sudden-Onset
|
0.300 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Adenocarcinoma of large intestine
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Hyperammonemia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture.
|
15606904 |
2005 |
|
Sepsis
|
0.200 |
Biomarker
|
disease |
RGD |
Heat shock pretreatment influences the expression of PKC isoforms during sepsis.
|
11735277 |
2001 |
|
Insulin Resistance
|
0.200 |
Biomarker
|
phenotype |
RGD |
Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.
|
10923637 |
2000 |
|
Insulin Resistance
|
0.200 |
Biomarker
|
phenotype |
RGD |
Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.
|
9000691 |
1997 |
|
Hyperinsulinism
|
0.200 |
Biomarker
|
disease |
RGD |
Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis.
|
8826977 |
1996 |