Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.050 Biomarker phenotype BEFREE Extra-cellular signal regulated kinase-5 (Erk-5), a transcriptional activator and regulator of endothelial cells (ECs) homeostasis, has been implicated in shear stress-induced endothelial dysfunction (ED), however its role in oxidized low-density lipoprotein (oxLDL)- induced ED during metabolic stress is not known. 31199942 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.050 Biomarker phenotype BEFREE In conclusion, shear stress counteracts endothelial dysfunction by suppressing the pro-inflammatory non-canonical TGF-β pathway and by activating the ERK5 pathway which restores redox signalling. 28209993 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.050 Biomarker phenotype BEFREE Interestingly, in ERK5-EKO mice, increased leukocyte rolling and impaired vessel reactivity were resistant to the beneficial effects of fluoromethyl ketone-methoxyethylamine, suggesting a critical role for endothelial ERK5 in mediating the salutary effects of fluoromethyl ketone-methoxyethylamine on endothelial dysfunction. 23243209 2013
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.050 Biomarker phenotype BEFREE Among them, ERK5-sumoylation has recently been linked to diabetes and implicated in endothelial dysfunction and cardiomyocyte apoptosis in vivo. 20079693 2010
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.050 AlteredExpression phenotype BEFREE These data clearly defined SUMOylation-dependent ERK5 transcriptional repression independent of kinase activity and suggested this process as among the molecular mechanisms of diabetes-mediated endothelial dysfunction. 18218985 2008