Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.070 Biomarker disease BEFREE <b>Objective:</b> To investigate the effects of miR-143-3p and MAPK7 on the proliferation, migration, and invasion of U2OS human osteosarcoma (OS) cells. 31126193 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.070 Biomarker disease BEFREE Our study aimed to evaluate the roles of mitogen-activated protein kinase 7 (MAPK7) in cell proliferation, migration and invasion using the SOSP-M human OS cell line as an in vitro model. 26350187 2017
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.070 Biomarker disease BEFREE MAPK7 gene controls proliferation, migration and cell invasion in osteosarcoma. 26460937 2016
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.070 Biomarker disease BEFREE ERK5 siRNA targeting ERK5 was stably transfected into the human osteosarcoma cell lines U2OS. 25317798 2014
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.070 Biomarker disease BEFREE Overexpression of these genes was significantly associated to a poor response to treatment (P = .0001 and P = .0049, respectively), tumor progression, and worse overall survival (P = .0052 and P = .0085, respectively), suggesting that MAPK7 and MAP2K4 could play an important role in osteosarcoma tumorigenesis. 22154052 2012
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.070 AlteredExpression disease BEFREE ERK5 was distinctly overexpressed in U2OS and primary OS cell. 22213073 2012
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.070 Biomarker disease BEFREE Our findings suggest that multiple amplification targets, including PMP22, TOP3A, and MAPK7 or genes close to these candidate oncogenes, may be present in 17p11.2 approximately p12 and thus contribute to osteosarcoma tumorigenesis. 12550767 2002