MYDGF, myeloid derived growth factor, 56005

N. diseases: 295; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.080 AlteredExpression disease BEFREE However, the molecular mechanism that regulates the colonic IL-25 expression in Crohn's disease (CD) remains unclear. 27901018 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.080 AlteredExpression disease BEFREE The IL-27 mRNA expression was increased in patients with active CD compared with inactive CD disease (P = 0.035). 27221243 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.080 GeneticVariation disease BEFREE Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population. 25674271 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.080 GeneticVariation disease BEFREE We identified a significant enrichment of methylation changes within 50 kb of CD GWAS loci (8.6-fold [P = 0.021] in adults; 2.4-fold [P = 0.009] in adults and children combined), including IL-27, IL-19, TNF, MST1, and NOD2. 22021194 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.080 Biomarker disease BEFREE IL-27 transcripts are significantly elevated in active Crohn's disease (CD) but not in ulcerative colitis (UC). 19686419 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.080 Biomarker disease BEFREE IL-1beta, IL-6, IL-12, and IL-27 were higher in affected areas compared to unaffected ones in UC but not CD. 19657406 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.080 AlteredExpression disease BEFREE Notably, increased expression of IL-23 and IL-27 transcripts in CD suggests a T helper 1-dominated immunologic function in this disease. 15674109 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.080 GeneticVariation disease BEFREE First, direct sequencing of the coding regions of the IL-25 gene in 40 patients with Crohn's disease or ulcerative colitis revealed only a newly reported polymorphism (c424C/A) in exon 2. 14641539 2003