|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Silencing of PDGF-C depleted tumor growth, increased vessel density and reduced vessel size.
|
30563292 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The positive expressions and mRNA levels of Tspan-1, VEGF, E-cadherin and N-cadherin were not correlated with sex or age (P>0.05), but associated with the cancer state (stage II or stage III) and maximum tumor diameter (P<0.05).
|
28927050 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice.
|
26122702 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, TAMs isolated from the PDGF-C knockdown murine breast cancer cell line 4T1 and PDGF-C knockdown MDA-MB-231-derived tumor mass showed higher rates of apoptosis than the respective WT controls.
|
24421315 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the liver of patients with non-recurrence, expression of PDGFC and other angiogenesis genes, cancer stem cell marker genes, and genes related to tumor progression was down-regulated, while expression of genes related to hepatocyte differentiation, tumor suppression genes, and other genes related to apoptosis induction was up-regulated.
|
23587162 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results indicate that PDGF-C upregulation and calpain-3 downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins or their downstream effectors may synergise with VEGF‑A therapies in combating tumour-associated angiogenesis and melanoma spread.
|
24126726 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data indicate that PDGF-C promotes tumor growth via a growth promoting effect on HSC that is at least in part dependent on the presence of functional PAK-2.
|
22362252 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, PDGF-C enhances tumour cell invasion in the presence of fibroblasts, suggesting a role for tumour-derived PDGF-C in tumour-stromal interactions.
|
22035541 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of PDGFC in a mouse model accelerated tumor growth through recruitment and activation of different subsets of cancer-associated fibroblasts.
|
19118022 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, we showed that Calu-6 tumors express significant levels of PDGFC, and that the levels of expression of these two PDGFRalpha ligands correlate strongly with the degree of stromal fibroblast infiltration into the tumor mass.
|
16675559 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Microarray gene expression data were confirmed using quantitative reverse transcriptase-polymerase chain reaction and protein analysis for three novel candidate oncogenes (NME2, CRI1, and PDGFC) and one candidate tumor suppressor (GSN).
|
15920167 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.
|
11313995 |
2001 |