Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology. 24436253 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 GeneticVariation disease BEFREE A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology. 24436253 2014
CUI: C0005910
Disease: Body Weight
Body Weight 		0.300 Biomarker phenotype CTD_human Meta-analysis identifies common variants associated with body mass index in east Asians. 22344219 2012
CUI: C0236733
Disease: Amphetamine-Related Disorders
Amphetamine-Related Disorders 		0.300 Biomarker group CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0236804
Disease: Amphetamine Addiction
Amphetamine Addiction 		0.300 Biomarker disease CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0236807
Disease: Amphetamine Abuse
Amphetamine Abuse 		0.300 Biomarker disease CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 Biomarker disease BEFREE Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. 29422930 2018
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 Biomarker disease BEFREE Our findings directly link MEIS1 and SKOR1, two significantly associated genes with RLS and also prioritize SKOR1 over MAP2K5 in the RLS associated intergenic region of MAP2K5/SKOR1 found by GWAS. 30111810 2018
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846 2017
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 Biomarker disease BEFREE Our results confirmed the association of BTBD9 and MAP2K5/SKOR1 with primary RLS in Chinese population. 28329290 2017
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology. 24436253 2014
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 Biomarker disease BEFREE Variants in MEIS1, BTBD9, and MAP2K5/SKOR1 confer a significant risk of RLS in a US population. 21925394 2011
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE In the German sample, variants in MEIS1 and BTBD9 were associated with RLS in ESRD (P(nom)≤0.004, ORs 1.52 and 1.55), whereas, in the Greek sample, there was a trend for association to MAP2K5/SKOR1 and BTBD9 (P(nom)≤0.08, ORs 1.41 and 1.33). 21572129 2011
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASDB Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176 2011
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASCAT Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176 2011
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q. 19279021 2009
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASCAT Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE In a genome-wide association study we found highly significant associations between RLS and intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well as variants in a third locus containing the genes encoding mitogen-activated protein kinase MAP2K5 and the transcription factor LBXCOR1 on chromosomes 2p, 6p and 15q, respectively. 17637780 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE Genetic risk variants for RLS have recently been identified in two genes, one of them the homeobox gene MEIS1, known to be involved in embryonic development and variants in a second locus containing the genes encoding mitogen-activated protein kinase MAP2K5, and the transcription factor LBXCOR1. 18081164 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease BEFREE Association (Bonferroni corrected) of rs543874 near SEC16B and rs2241423 near MAP2K5 had presumably stronger effects on obesity in Chinese children than in Caucasian populations. 26800887 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease BEFREE After adjusting for age, sex and multiple testing, MC4R rs17782313, SEC16B rs543874, MAP2K5 rs2241423 and KCTD15 rs11084753 were associated with obesity and obesity-related traits (all P<0.005), with odd ratios ranging from 1.22 to 2.15. 25637721 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease GWASDB Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease GWASCAT Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease BEFREE rs2241423 was associated with BMI and obesity in two independent European cohorts suggesting a role for MAP2K5 in early weight regulation. 22594783 2012