PRL, prolactin, 5617

N. diseases: 506; N. variants: 3
Disease: Pituitary Adenoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease BEFREE Although lipid extracts of PAs showed the presence of many common lipid molecules, only glycerophosphoethanolamine (GPE) showed statistically significant decrease in PRL, ACTH and non-functional subtypes when compared to LH/FSH-secreting tumors. 30816132 2019
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease BEFREE Pituitary adenomas (PAs) are one of the most common intracranial tumors; approximately half of PAs are prolactin (PRL)-secreting PAs (prolactinomas). 31692290 2019
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 GeneticVariation disease BEFREE Prolactin Variants in Human Pituitaries and Pituitary Adenomas Identified With Two-Dimensional Gel Electrophoresis and Mass Spectrometry. 30210449 2018
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 AlteredExpression disease BEFREE Pituitary magnetic resonance imaging (MRI) was performed in PCOS patients with PRL levels ≥94.0 ng/mL and/or symptoms suspicious of a pituitary adenoma (PA). 29845629 2018
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease BEFREE Pituitary adenoma (PA) is a common type of benign tumor of the pituitary gland that is characterized by specific signs and symptoms, primarily associated with hypersecretion of pituitary glycoprotein hormones (thyroid-stimulating, growth and adrenocorticotrophic hormones, and prolactin). 28599454 2017
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease BEFREE Also, the NDRG2 expression was significantly higher in prolactinoma (PRL hypersecretion) than in in other diagnoses of PAs (p < 0.05). 28390436 2017
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease BEFREE PD-L1 RNA and protein expression were significantly increased in functioning (growth hormone and prolactin-expressing) pituitary adenomas compared to non-functioning (null cell and silent gonadotroph) adenomas. 27655724 2016
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 AlteredExpression disease BEFREE D2R high expression existed more frequently in PRL- and GH- secreting PAs. 25027022 2014
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease BEFREE Thus, germline AIP or MEN1 gene mutations are frequent among pediatric patients with GH- or PRL-secreting PA but are significantly rarer in pediatric CD; PRKAR1A mutations are not present in PA outside of Carney complex. 20507346 2010
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease BEFREE Does prolactin releasing peptide receptor regulate prolactin-secretion in human pituitary adenomas? 10984631 2000
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 GeneticVariation disease BEFREE Present and earlier data on 23 PAs showed that tumors with the highest frequency of abnormal karyotypes revealed by cytogenetics and/or interphase FISH were PRL (78%), followed by NFPA (26%) and GH (18%). 10760821 2000
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease BEFREE These results indicate that a) there is a differential distribution of PC1 in human pituitary adenomas with PRL adenomas expressing very little PC1 mRNA and protein and b) that PC1 expression in gonadotropin hormone-producing adenomas is regulated by PMA and TGF beta 1. 11081197 1999
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease CTD_human [Morphological changes in prolactinoma induced by bromocriptine treatment]. 2274009 1991
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Therapeutic disease CTD_human [Morphological changes in prolactinoma induced by bromocriptine treatment]. 2274009 1991
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease CTD_human Rapid decrease in amino acid metabolism in prolactin-secreting pituitary adenomas after bromocriptine treatment: a PET study. 3498743 1987
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Therapeutic disease CTD_human Rapid decrease in amino acid metabolism in prolactin-secreting pituitary adenomas after bromocriptine treatment: a PET study. 3498743 1987
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Therapeutic disease CTD_human Synergism of diethylstilbestrol and other carcinogens in concurrent development of hepatic, mammary, and pituitary tumors in castrated male rats. 6156259 1980
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		0.400 Biomarker disease CTD_human Synergism of diethylstilbestrol and other carcinogens in concurrent development of hepatic, mammary, and pituitary tumors in castrated male rats. 6156259 1980