Plaque, Amyloid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We developed a cell model of Gerstmann-Sträussler-Scheinker disease, a neurodegenerative condition characterized by PrPM-containing amyloid deposits and neuronal loss, by expressing the Gerstmann-Sträussler-Scheinker haplotype Q217R-129V in human neuroblastoma cells.
|
9353306 |
1997 |
Plaque, Amyloid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Different PrP(sc) "type"-PRNP genotype combinations are found associated with pathological phenotypes that differ in the relative severity of lesions among distinct brain regions, the presence and morphology of certain lesions such as amyloid plaques, and the pattern of intracerebral and tissue deposition of PrP(sc).
|
10871544 |
2000 |
Plaque, Amyloid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The amount of PrP deposition including florid/amyloid plaques in the brain also gradually decreased from 129M/M to 129M/V and to 129V/V.
|
23792955 |
2013 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Met/Met cases (mild lesions mostly involving the occipital areas, low PrP load, few focal PrP nonamyloid deposits, no amyloid plaques) contrasted with Met/Val cases (marked lesions especially in the parahippocampal gyrus, high PrP load, numerous amyloid plaques) and with Val/Val cases (younger patients, longer course of disease: 11.5 +/- 3 months, and distinct neuropathology: severe lesions heavily involving the hippocampal formation and basal ganglia, high PrP load, numerous focal nonamyloid deposits, rare amyloid plaques).
|
10762506 |
2000 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some transgenic (Tg) mouse (Mo) lines that carry and express a Syrian hamster (Ha) PrP gene developed scrapie 75 d after inoculation with Ha prions; non-Tg mice failed to show symptoms after greater than 500 d. Brains of these infected Tg(HaPrP) mice featured protease-resistant HaPrPSc, amyloid plaques characteristic for Ha scrapie, and 10(9) ID50 units of Ha-specific prions upon bioassay.
|
1684745 |
1991 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that strategies targeting the interaction between PrP and OC-positive oligomers, which have been shown to be highly concentrated in the vicinity of amyloid plaques, may have therapeutic potential against Alzheimer's disease.
|
31808343 |
2020 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histopathologic features consist of distinctive "curly" prion protein deposits with a strictly laminar distribution in the cerebral cortex and minimal astrogliosis in the absence of amyloid plaques or spongiosis.
|
10953183 |
2000 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two types of anti-PrP-immunoreactive deposits were found: (i) amyloid deposits, which were exclusively labeled by anti-P1 antiserum to residues 90-102 of PrP, and (ii) preamyloid deposits, which were labeled by all anti-PrP antisera but did not exhibit the tinctorial and optical properties of amyloid.
|
1357663 |
1992 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The amyloid deposits in the cerebellum and basal ganglia gave a positive immunoperoxidase staining reaction for PrP.
|
8513392 |
1993 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
One fundamental mechanistic event in prion diseases is the aggregation of aberrantly folded prion protein into large amyloid plaques and fibrous structures associated with neurodegeneration.
|
18233951 |
2008 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study shows that PrP-amyloid plaques can occur in the white matter of sCJD-MM1 cases.
|
18751990 |
2008 |