|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytoprotective APC therapy holds promise for the treatment of ischemic stroke, and a recently completed trial suggested that cytoprotective-selective 3K3A-APC reduced bleeding in ischemic stroke patients.
|
31348046 |
2019 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thrombin aggravates ischemic stroke and activated protein C (APC) has a neuroprotective effect.
|
30718498 |
2019 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analogs of activated protein C (APC) exert pleiotropic anti-inflammatory, anti-apoptotic, antithrombotic, cytoprotective, and neuroregenerative effects in ischemic stroke and thus appear to be promising candidates for this novel approach.
|
28923278 |
2018 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using these strains, we determined whether or not recombinant murine signaling-selective APC mutants would reduce septic death or provide neuroprotection against ischemic stroke when mice carried PAR1-homozygous mutations that prevent cleavage at either R41 or R46.
|
29343482 |
2018 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
These recent advances should encourage translational research centered on signaling selective APC's for both single-agent therapies and multiagent combination therapies for ischemic stroke and other neuropathologies.
|
29866816 |
2018 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, this study reveals the importance of APC glycosylation in controlling the efficacy of PAR1 proteolysis by APC and demonstrates the potential of novel APC variants with superior cytoprotective signaling function as enhanced therapeutic agents for the treatment of ischemic stroke.
|
26084674 |
2015 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothelial protein C receptor (EPCR) dependent and likely underlie protective effects of APC in animal models of sepsis, myocardial infarction and ischemic stroke.
|
25032959 |
2014 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Remarkably, pharmacologic therapy using APC demonstrates substantial neuroprotective effects in various murine injury models, including ischemic stroke.
|
22477541 |
2012 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
In mice, treatment of experimental ischemic stroke with activated protein C improves outcomes; however, activated protein C also has bleeding side effects.
|
21512172 |
2011 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, 3K3A-APC exhibits species-dependent neuroprotection which should be taken into account when designing human trials for ischemic stroke with APC mutants.
|
19166505 |
2009 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Drotrecogin-alfa activated, a hyperanticoagulant form of human recombinant APC, is currently being studied in patients with ischemic stroke.
|
19057019 |
2009 |