|
Adrenal Gland Pheochromocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pheochromocytoma cells (PC12), exposed to high concentration of zinc (400µM), were used to determine the protective effect of NAP on Tau phosphorylation and two Tau kinases (Fyn and GSK-3β).
|
30417779 |
2018 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was aimed to assess whether systemic/intraperitoneal and/or mucosal HP-NAP administration inhibited the Th2-mediated bronchial inflammation using a mouse model of allergic asthma induced by inhaled ovalbumin (OVA).
|
18671823 |
2008 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effect of NAP on Abeta and tau pathology using a transgenic mouse model that recapitulates both aspects of AD.
|
17478890 |
2007 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Addressing Alzheimer's disease tangles: from NAP to AL-108.
|
19874271 |
2009 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, aluminum ions may increase the risk for neurotoxicity in AD, and the use of NAP is suggested as a treatment to provide additional protection against the effects of aluminum ions, via EEA1 and PI3KR2, associated with sorting and processing of the AD amyloid precursor protein (APP) through the endosomal system.
|
30987727 |
2019 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage.
|
17478890 |
2007 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
NAP but not Risperidone, reduced anxiety in the mutated mice.
|
26553741 |
2015 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
NAP but not Risperidone, reduced anxiety in the mutated mice.
|
26553741 |
2015 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we constructed a CTB-NAP fusion protein on the surface of Bacillus subtilis spore and evaluate the efficiency of oral administration of the recombinant CTB-NAP spores in preventing asthma in mice.
|
28608279 |
2017 |
|
Atrial Fibrillation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Univariate analysis showed that the AP-MT group was older (P<0.001), more often had atrial fibrillation (P<0001), and had a higher ASPECTS (P<0.006 and P<0.002) compared with the NAP-MT group and NAP-IVTMT groups, respectively.
|
29602862 |
2018 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings tie for the first time a reduction in presynaptic glutamatergic synapses with the autism/Alzheimer's/schizophrenia-linked ADNP deficiency coupled with amelioration by NAP (CP201).
|
30664622 |
2019 |
|
Body mass index procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.
|
18325910 |
2008 |
|
Bone Density
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
|
17903296 |
2007 |
|
Bone Mineral Density Test
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
|
17903296 |
2007 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The direct effect of HP-NAP on gastric epithelial cells may be limited, but HP-NAP may contribute to inflammatory response or carcinogenesis by activating neutrophils.
|
19452583 |
2009 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Toll-like receptor agonist rMBP-NAP enhances antitumor cytokines production and CTL activity of peripheral blood mononuclear cells from patients with lung cancer.
|
30214604 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spliceosome-associated factor CTNNBL1 promotes proliferation and invasion in ovarian cancer.
|
28501461 |
2017 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of these four proteins, EEA1 and PI3KR2 were down-regulated after NAP-induced neuroprotective activity in neuroblastoma cells.
|
30987727 |
2019 |
|
Cerebellar degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
ATM also interacts in vitro with beta-NAP, a neuronal-specific beta-adaptin homolog that was identified as an autoantigen in a patient with cerebellar degeneration.
|
9707615 |
1998 |
|
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of these four proteins, EEA1 and PI3KR2 were down-regulated after NAP-induced neuroprotective activity in neuroblastoma cells.
|
30987727 |
2019 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Whereas NAP application did not alleviate macroscopic (i.e. clinical) sequelae of colitis, lower numbers of apoptotic, but higher counts of proliferating/regenerating colonic epithelial cells could be observed in NAP as compared to placebo treated mice at day 7 p.i.
|
29288684 |
2018 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/beta-catenin complex.
|
19082443 |
2009 |
|
Delinquent behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Longitudinal path analysis indicated mediation of the relationship between NAP and peer delinquency by sexual maturation.
|
25156223 |
2014 |
|
Dental Pulp Necrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The maintenance of AP in molar teeth with necrotic pulp and apical periodontitis was associated with less postoperative pain when compared with NAP.
|
29370942 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
What's more, the antidepressant effect in social isolation-rearing mice was observed after intranasal administration of NT4-NAP/AAV, suggesting that this might be a promising therapeutic strategy for depressive disorder.
|
28052034 |
2017 |