|
Deep Vein Thrombosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Multivariate logistic analysis revealed that the presence of LA, aCL, anti-beta2-glycoprotein I, anti-prothrombin and anti-protein C Abs was not reliable as a risk factor for DVT in non-SLE patients, and that the presence of anti-protein S Abs was the most significant risk factor for DVT (OR, 5.88; 95% CI, 1.96-17.7; p < 0.002).
|
12428083 |
2002 |
|
Deep Vein Thrombosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this report, we present a case of recurrent pulmonary embolism (PE) and deep venous thrombosis (DVT) due to PS deficiency.
|
29742732 |
2018 |
|
Deep Vein Thrombosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Stroke in low PC infants and deep vein thrombosis in low PS/AT school age children could be targeted for genetic screening of pediatric thrombophilias.
|
26372516 |
2016 |
|
Deep Vein Thrombosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Taken together, this suggested that E(2) might repress PROS1 transcription depending upon ERalpha-Sp1 recruiting transcriptional repressors in HepG2-ERalpha cells and, consequently, that high levels of E(2) leading to reduced levels of plasma PS would be a risk for deep venous thrombosis in pregnant women.
|
20200160 |
2010 |
|
Deep Vein Thrombosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
One novel and one recurrent mutation in the PROS1 gene cause type I protein S deficiency in patients with pulmonary embolism associated with deep vein thrombosis.
|
16868938 |
2006 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
This article reviews the literature to understand PS and congenital PS deficiency, especially the association of this thrombophilia with pregnancy.
|
16026279 |
2005 |
|
Thrombophilia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Thrombophilia screening after the complete resolution consistently showed mildly decreased protein S (PS) activity with normal PS antigen levels.
|
21285903 |
2011 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hereditary protein S (PS) deficiency is one of the natural anticoagulant deficiencies causing thrombophilia.
|
31422373 |
2020 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Investigation for thrombophilia revealed protein S (PS) deficiency in this patient.
|
18434709 |
2008 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Previously reported polymorphisms and point mutations leading to PS deficiency and thrombophilia have been analyzed with our structural predictions.
|
9408945 |
1997 |
|
Thrombophilia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Because individuals affected by the R338L mutation have normal concentrations of PS, we speculated that the Padua hypercoagulation phenotype is due to decreased inhibition of FIXa R338L by PS.
|
30189336 |
2018 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Deficiencies of natural anticoagulant proteins including antithrombin (AT), protein C (PC) and protein S (PS) are important causes of inherited thrombophilia.
|
22627591 |
2012 |
|
Thrombophilia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we identified unique genomic architectures in the intervening sequences of PROS1 that underlie a large intragenic tandem duplication mutation leading to inherited thrombophilia.
|
24992033 |
2014 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Anticoagulant protein S (PS) deficiency is a known risk factor for thrombophilia.
|
10790208 |
2000 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hereditary protein S (PS) deficiency is a rare autosomal disorder of the coagulation pathway associated with familial thrombophilia.
|
12681974 |
2003 |
|
Thrombophilia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of PROC and PROS1 single nucleotide polymorphisms in a thrombophilia family.
|
31295762 |
2019 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Both PC and PS deficiencies have been implicated in thrombophilia.
|
9241706 |
1997 |
|
Thrombophilia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We processed 10,571 'thrombophilia' related test requests, including antithrombin (AT; n=3470), PC (n=3569), PS (n=3585), APCR (n=2359), factor V Leiden (FVL; n=2659), and prothrombin gene mutation (PGM; n=2103).
|
30485173 |
2019 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Because of the presence of a pseudogene and two different forms of PS in plasma, a bound and a free form, it is one of the most difficult thrombophilias to study.
|
18479427 |
2008 |
|
Thrombophilia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Detected with conventional laboratory tests high-risk thrombophilia was present in 70 patients: deficiencies of antithrombin (AT) (n = 12), protein C (PC) (n = 14), protein S (PS) (n = 6), homozygous factor V Leiden (FVL) mutation (n = 9) and combined types (n = 29).
|
29782332 |
2018 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thrombophilia due to protein C (PC) and protein S (PS) deficiencies is highly prevalent among patients with stage 5 chronic kidney disease and is reported to arise due to extracorporeal circulation during hemodialysis (HD).
|
31138132 |
2019 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
In the Chinese population, PS and PC deficiencies are common thrombophilia for VTE during pregnancy and thrombophilia screening should be recommended in all pregnant women who suffer from VTE.
|
22398278 |
2012 |
|
Thrombophilia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The frequency of thrombophilia, such as antithrombin (AT), protein C (PC), or protein S (PS) gene mutations, was examined in 21 patients with PVT, 6 patients with SMVT, and 6 patients with both PVT and SMVT.
|
29747524 |
2018 |
|
Thrombophilia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A novel mutation in intron K of the PROS1 gene causes aberrant RNA splicing and is a common cause of protein S deficiency in a UK thrombophilia cohort.
|
9657428 |
1998 |
|
Thrombophilia
|
0.200 |
Biomarker
|
disease |
BEFREE |
We studied the prevalence of antithrombin III (AT III), protein C (PC) and protein S (PS) deficiencies and factor V Leiden mutation in thrombophilia in Taiwan.
|
9271815 |
1997 |