|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of PRSS1 or PRSS1<sup>R122H</sup> increased focal damage in pancreatic tissues and increased the severity of acute pancreatitis after caerulein injection.
|
31419436 |
2020 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of pooled analyses showed that CLDN2 rs7057398, MORC4 rs12688220 and PRSS1-PRSS2 rs10273639 polymorphisms were all significantly associated with susceptibility to acute pancreatitis in Caucasians.
|
31163246 |
2020 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Disruption of the locus that encodes cationic trypsinogen in mice (T7) causes loss of expression of the protein, but only partially decreases the severity of secretagogue-induced acute pancreatitis and has no effect on chronic pancreatitis.
|
31751559 |
2020 |
|
Acute pancreatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Having a variant from CFTR, SPINK1 or PRSS1, was associated with the faster progression from AP to CP over time (p < 0.05).
|
31088717 |
2019 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The progression to CP is faster in children who were 6 years or older at the first episode of AP or with pathogenic PRSS1 variants.
|
31136562 |
2019 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP.
|
29884332 |
2018 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Early-onset disease was associated with mutations in cationic trypsinogen (PRSS1) (P < .01), chymotrypsin C (CTRC) (P = .01), family history of acute pancreatitis (P = .02), family history of CP (P < .01), biliary cysts (P = .04), or chronic renal failure (P = .02).
|
28502372 |
2017 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We confirmed a robust association of polymorphism rs10273639 at PRSS1-PRSS2 with AP in the Russian population.
|
27846138 |
2017 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The study's objective was to assess the association between the PRSS1 R122H and N29I and the SPINK1 N34S mutations and acute pancreatitis (AP) and recurrent pancreatitis in Mexican pediatric patients.
|
22699143 |
2012 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PRSS1 p.R122H mutation, SPINK1 p.N34S, and PRSS3 p.E32del variants were associated with recurrent, but not sentinel AP.
|
21303407 |
2011 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The etiology of acute pancreatitis (AP) seems to have changed during the last two decades, and since detection of mutations in the gene for cationic trypsinogen(PRSS1) causing hereditary pancreatitis some patients formerly diagnosed with idiopathic AP (IAP) turn out to have a genetic cause.
|
20720446 |
2010 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Attacks of acute pancreatitis in HP subjects appear to be independent of the relative expression of the mutant PRSS1 H122 allele or SPINK1 gene expression.
|
16354799 |
2006 |
|
Acute pancreatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The identification of a second mutation in the cationic trypsinogen gene (HP2) suggests a dominant role of trypsin in premature protease activation-mediated forms of acute pancreatitis.
|
9322498 |
1997 |