Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, whether PRSS1 mutations trigger pancreatic cancer and/or promote malignant proliferation and metastasis in pancreatic cancer remains largely unclear, as well as the potential underlying mechanisms.
|
31521106 |
2019 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The multicenter surveillance program included asymptomatic HRIs with familial (FPC) or genetic frailty (GS: BRCA1/2, p16/CDKN2A, STK11/LKB1or PRSS1, mutated genes) predisposition to PC.
|
30538291 |
2019 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thirty-seven PRSS1 carriers (30 symptomatic, 7 asymptomatic) were deceased at conclusion of the study (5 from pancreatic cancer).
|
30018304 |
2018 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While the substantially elevated risk of pancreatic cancer in patients with PRSS1 gene mutations with chronic pancreatitis has been well established, little is known about the risk of pancreatic cancer in SPINK 1 gene mutation carriers with pancreatitis.
|
27358244 |
2017 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results presented here have provided a greater insight into the PRSS1 mutations and proteinase-inhibitor interactions occurring in pancreatic cancer.
|
26546433 |
2016 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the cationic trypsinogen (PRSS1), cystic fibrosis transmembrane conductance regulator (CFTR), serine protease inhibitor Kazal type 1 (SPINK1), and chymotrypsin C (CTRC) genes are associated with an elevated risk for chronic pancreatitis, which is a known risk factor for pancreatic cancer (PC).
|
25003218 |
2014 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A heterozygous CTRC-deleting complex rearrangement, which was co-inherited with different trans variants in SPINK1, CFTR or PRSS1, is associated with variable phenotypes (chronic pancreatitis; pancreatic cancer and chronic pancreatitis; and type 1 diabetes).
|
23721890 |
2013 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to describe specific novel mutations in the intron of the PRSS1 gene in patients with pancreatic cancer and CP.
|
22109105 |
2012 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genotypes of PRSS1 were determined in 154 patients with pancreatic cancer and in a control group of 520 healthy individuals of Han Chinese descent.
|
21922221 |
2012 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were two patients who carried novel mutations which was IVS 3 + 157 G > C of PRSS1 gene in peripheral blood specimens and pancreatic cancer tissue.
|
22088471 |
2011 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Inherited risk of pancreatic cancer has been associated with mutations in several genes, including BRCA2, CDKN2A (p16), PRSS1, and PALB2.
|
19690177 |
2009 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results sustain the knowledge about the clinical phenotype of patients with PRSS1 mutations who have a high risk of pancreatic cancer.
|
18946221 |
2008 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significantly, the risk of pancreatic cancer is not related to PRSS1 mutation type and does not appear to be related to the mode of inheritance.
|
15749231 |
2005 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate mutation of serine protease 1-cationic trypsinogen (CT, PRSS1) gene in members of a Thai family with hereditary pancreatitis and pancreatic cancer.
|
15786540 |
2005 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significantly, the risk of pancreatic cancer is not related to PRSS1 mutation type and does not appear to be related to the mode of inheritance.
|
15528017 |
2004 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the cationic trypsinogen gene are acknowledged as a risk factor for pancreatic cancer in patients with hereditary pancreatitis.
|
15084977 |
2004 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in the BRCA2, CDKN2A/p16, hMSH2, hMLH1, hPMS1, hPMS2, LKB1/STK1, and PRSS1 genes have been associated with increased risk for pancreatic cancer.
|
12120238 |
2001 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the quantitative contribution of mutations in the cationic trypsinogen gene to all pancreatic cancer cases is unknown.
|
11062709 |
2000 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A review of the ongoing hereditary pancreatitis study of the Midwest Multicenter Pancreatic Study Group suggests that the risk of pancreatic cancer is related to long-standing pancreatitis rather than to the cationic trypsinogen mutations.
|
10415865 |
1999 |
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A small proportion of cases results from inherited predisposition due to germline transmission of a mutated CDKN2 or BRCA2 gene, while patients with familial pancreatitis due to a mutated cationic trypsinogen gene have a greatly increased risk of developing pancreatic cancer.
|
9438601 |
1997 |