PRSS2, serine protease 2, 5645

N. diseases: 66; N. variants: 14
Disease: Pancreatitis, Chronic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease BEFREE Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP. 29884332 2018
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease BEFREE A recent genome-wide association study (GWAS) identified association with variants in X-linked CLDN2 and MORC4, and PRSS1-PRSS2 loci with chronic pancreatitis (CP) in North American patients of European ancestry. 26820620 2016
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease BEFREE In this study, we evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic RAP and CP. 26110235 2015
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease BEFREE A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1-PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2-MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4). 25253127 2015
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease BEFREE However mutations in cationic and anionic trypsinogen gene do not play an important role in causing CP in Asia Pacific region. 21323990 2011
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease BEFREE It has been recently shown that a loss-of-function variant, c.571G>A (p.G191R), in the anionic trypsinogen (PRSS2) gene protects against chronic pancreatitis in European populations. 19052022 2009
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease LHGDN A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. 18362849 2008
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 Biomarker disease CTD_human Hereditary chronic pancreatitis. 18206817 2008
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 Biomarker disease CTD_human A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. 16699518 2006
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 AlteredExpression disease LHGDN A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. 16699518 2006
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease BEFREE In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis. 16699518 2006
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease LHGDN Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl. 15776435 2005
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 GeneticVariation disease BEFREE Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl. 15776435 2005
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 Biomarker disease HPO