Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
BEFREE |
This gene's protein Reelin, which is necessary for neuronal migration and synaptogenesis, is reduced in schizophrenia and bipolar disorder, suggesting hypermethylation of the promoter region in these disorders.
|
15108180 |
2004 |
Bipolar Disorder
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons.
|
25364290 |
2014 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
PSYGENET |
We evaluated whether an RELN gene variant, rs362719, which has been associated with increased susceptibility to bipolar disorder, is also associated with susceptibility to schizophrenia.
|
21863557 |
2011 |
Bipolar Disorder
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Post-mortem studies have shown lower Reelin protein levels in the brains of patients with schizophrenia and bipolar disorder (BP) compared with controls.
|
19691043 |
2010 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
CTD_human |
We present new immunocytochemical evidence showing reductions in Reelin expression in hippocampus of subjects with schizophrenia, bipolar disorder and major depression and confirm recent reports documenting a similar deficit involving Reelin expression in brains of subjects with schizophrenia and bipolar disorder.
|
11126396 |
2000 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
PSYGENET |
Previous results have revealed that reelin levels are decreased in post-mortem hippocampal tissue from patients with schizophrenia, bipolar disorder and depression, and also in an animal model of depression.
|
20849864 |
2011 |
Bipolar Disorder
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
A research strategy directed toward identifying specific neurochemical markers operative in the etiopathology of psychotic disorders lead to the identification of a downregulation (30-50%) of Reln and glutamic acid decarboxylase 67(GAD67) expression in prefrontal cortex and other brain areas of schizoprenia and bipolar disorder patients with psychosis.
|
11059795 |
2000 |
Bipolar Disorder
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression.
|
28583708 |
2020 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
CTD_human |
We employed SDS-PAGE and Western blotting to measure levels of GAD isomers 65 and 67 kDa and Reelin isoforms 410-, 330- and 180-kDa proteins as well as beta-actin in cerebellum of subjects with schizophrenia, bipolar disorder and major depression vs. controls (N = 15 per group).
|
15560956 |
2005 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
BEFREE |
Reelin (RELN) is identified as a risk gene for major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD).
|
26637325 |
2016 |
Bipolar Disorder
|
0.570 |
GeneticVariation
|
disease |
BEFREE |
We evaluated whether an RELN gene variant, rs362719, which has been associated with increased susceptibility to bipolar disorder, is also associated with susceptibility to schizophrenia.
|
21863557 |
2011 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
PSYGENET |
Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons.
|
25364290 |
2014 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
PSYGENET |
A number of neuropsychiatric disorders including autism, schizophrenia, bipolar disorder, major depression, Alzheimer's disease and lissencephaly share a common feature of abnormal Reelin expression in the brain.
|
22981949 |
2013 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
CTD_human |
In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065).
|
14708030 |
2004 |
Bipolar Disorder
|
0.570 |
Biomarker
|
disease |
PSYGENET |
Recent studies have shown that Reelin, an extracellular protein that is critical for neuronal development, is reduced in schizophrenia and bipolar disorder patients.
|
21814183 |
2011 |