|
Iron deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that ID during the postweaning period in male rats, despite complete iron repletion following ID, led to long-term hyperactivity via monoamine disturbance in the brain and an alteration in the synaptic plasticity accompanied by downregulation of Reln expression in the NAcc.
|
31599944 |
2020 |
|
Mitral Valve Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using immunoblot or slot-blot techniques, we confirmed decreased levels of protein kinase C-binding protein NELL2, neural cell adhesion molecule L1-like protein, and reelin in MS+ patients.
|
29961995 |
2019 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons.
|
31230943 |
2019 |
|
Ataxia Telangiectasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ataxia telangiectasia alters the ApoB and reelin pathway.
|
30343341 |
2018 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the functional level, we found RELN to regulate glioblastoma cell migration both in a DAB1 (tyrosine phosphorylation)-dependent and -independent fashion, depending on the substrate provided.
|
29222813 |
2018 |
|
Atrial Septal Defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This study aimed to provide additional evidence for the association between two SNPs of RELN (i.e., rs736707, rs2229864) and ASD risk, as well as the relationship between RELN gene and symptom-based and developmental deficits of ASD patients in Chinese Han children and adolescents.
|
29753726 |
2018 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the functional level, we found RELN to regulate glioblastoma cell migration both in a DAB1 (tyrosine phosphorylation)-dependent and -independent fashion, depending on the substrate provided.
|
29222813 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the functional level, we found RELN to regulate glioblastoma cell migration both in a DAB1 (tyrosine phosphorylation)-dependent and -independent fashion, depending on the substrate provided.
|
29222813 |
2018 |
|
Dyslexia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that not only RELN, but its interactors in the neuronal migration pathway may play roles in the etiology of dyslexia.
|
30199849 |
2018 |
|
Familial (FPAH)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our findings strengthen the association of TGFB1 (rs1800472) with otosclerosis and support a relationship between RELN and familial otosclerosis only, which may explain previous variable replications.
|
29728750 |
2018 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the functional level, we found RELN to regulate glioblastoma cell migration both in a DAB1 (tyrosine phosphorylation)-dependent and -independent fashion, depending on the substrate provided.
|
29222813 |
2018 |
|
ATRIAL SEPTAL DEFECT 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to provide additional evidence for the association between two SNPs of RELN (i.e., rs736707, rs2229864) and ASD risk, as well as the relationship between RELN gene and symptom-based and developmental deficits of ASD patients in Chinese Han children and adolescents.
|
29753726 |
2018 |
|
SPINOCEREBELLAR ATAXIA 37
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study reveals the unstable ATTTC repeat mutation within the DAB1 gene as the underlying genetic cause and provides evidence of reelin-DAB1 signalling dysregulation in the spinocerebellar ataxia type 37.
|
29939198 |
2018 |
|
Cerebrovascular Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
These results indicate that Reelin is an important regulator of GPIb-mediated platelet activation and may represent a new therapeutic target for the prevention and treatment of cardio- and cerebrovascular diseases.
|
28943410 |
2017 |
|
Developmental Disabilities
|
0.010 |
Biomarker
|
group |
BEFREE |
Loss of Reelin function results in the severe developmental disorder lissencephaly and is associated with neurological diseases in humans.
|
28484035 |
2017 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
On this basis, Reelin expression was analysed by immunohistochemistry during liver biopsies of 81 patients with HCV-related chronic hepatitis.
|
28348420 |
2017 |
|
Hyperalgesia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Mutant mice with a deletion of Reelin, its lipoprotein receptors, or its intracellular adaptor protein Disabled-1 (Dab1), exhibit nociceptive abnormalities: thermal (heat) hyperalgesia and reduced mechanical sensitivity.
|
28083884 |
2017 |
|
Creutzfeldt-Jakob disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reelin Expression in Creutzfeldt-Jakob Disease and Experimental Models of Transmissible Spongiform Encephalopathies.
|
27726110 |
2017 |
|
Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
There results suggest that reelin played essential roles in the development of lymphoma and might be a potential drug target in lymphoma.
|
28498462 |
2017 |
|
Lymphoma, Non-Hodgkin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Then, the expression of Reelin was silenced with short hairpin RNA (shRNA)-expressing plasmid in the NHL cell line A20.
|
28498462 |
2017 |
|
Stereotypic Movement Disorder
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we show that selective overexpression of the stress protein, heme oxygenase-1 (HO-1) in astrocytes of GFAP.HMOX1 transgenic mice between 8.5 and 19 months of age results in nigrostriatal hypodopaminergia associated with locomotor incoordination and stereotypy; downregulation of tyrosine hydroxylase, DAT, LMX1B, Nurr1, Pitx3 and DJ-1 mRNA and/or protein; overproduction of α-synuclein and ubiquitin; oxidative stress; basal ganglia siderosis; mitochondrial damage/mitophagy; and augmented GABAergic systems (increased GABA, GAD67 and reelin).
|
28746897 |
2017 |
|
Prion Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
With this is mind, in the present study, we determined that Reelin protein and mRNA levels increased in CJD human samples and in mouse models of human prion disease in contrast to murine models of prion infection.
|
27726110 |
2017 |
|
Adult Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of Reelin suppresses cell survival and mobility in non-Hodgkin lymphoma.
|
28498462 |
2017 |
|
Childhood Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of Reelin suppresses cell survival and mobility in non-Hodgkin lymphoma.
|
28498462 |
2017 |
|
Fibrosis, Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Reelin correlated with CRBP-1 positive cells (P=0.002), but not with alpha-SMA, suggesting that Reelin should not be regarded as a marker of hepatic stellate cells/myofibroblasts differentiation but rather as a functional protein expressed during some phases of liver fibrosis.
|
28348420 |
2017 |