RELN, reelin, 5649

N. diseases: 178; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.530 Biomarker disease BEFREE Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABA<sub>A</sub> Receptor Expression in a Preclinical Model of Depression. 29515447 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.530 Biomarker disease BEFREE Our findings underscore the importance of reelin in maintaining adult network stability and reveal a new mode for reactivating dendritogenesis in neurological disorders where dendritic arbor complexity is limited, such as in depression, Alzheimer's disease, and stroke.. 27653801 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.530 GeneticVariation disease BEFREE In the present study, we looked for a potential association between suicide and the reelin gene as reelin has been associated previously with several psychiatric disorders, including depression. 27537376 2016
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.530 Biomarker disease PSYGENET These results support our hypothesis that reelin plays a role in the pathogenesis of depression and suggest that reelin could be an important target for the development of novel therapeutics for the treatment of depression. 23608736 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.530 Biomarker disease PSYGENET In addition, we demonstrate that while stress increased NMDA NR2B-mediated synaptic transmission, known to be implicated in depression, Reelin overexpression significantly reduced it. 21814183 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.530 Biomarker disease PSYGENET Corticosterone produced dose-dependent increases in depression-like behavior and decreases in reelin expression, neurogenesis, and cell maturation regardless of mouse genotype. 20849864 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.530 Biomarker disease PSYGENET In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065). 14708030 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.530 Biomarker disease CTD_human In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065). 14708030 2004