|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Age-related macular degeneration (AMD), a complex multigenic disorder and the most common cause of vision loss in the elderly, is associated with polymorphisms in the LOC387715/ARMS2 and HTRA1 genes on 10q26.
|
18535016 |
2008 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
AMD donors carrying the ARMS2 and HTRA1 risk alleles were the most likely to exhibit elevated CEP markers.
|
19202148 |
2009 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
AMD donors carrying the ARMS2 and HTRA1 risk alleles were the most likely to exhibit elevated CEP markers.
|
20238042 |
2010 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.
|
23478260 |
2013 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
HTRA1 polymorphism in dry and wet age-related macular degeneration.
|
18301036 |
2008 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
LHGDN |
HtrA1 (G/A) SNP was successfully genotyped in 52 AMD cases and 13 non-AMD subjects.
|
18427598 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HTRA1 rs11200638 G→A polymorphism and LOC387715/ARMS2 rs10490924 G→T polymorphism play important roles in AMD.
|
21031019 |
2010 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HTRA1 gene polymorphism may influence patient response to treatment with intravitreal ranibizumab for neovascular AMD.
|
24080590 |
2013 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
High-temperature requirement A serine peptidase 1 (HTRA1) and age-related maculopathy susceptibility 2 (ARMS2) are two genes that are strongly associated with AMD.
|
28583181 |
2017 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
HtrA1 is a serine protease suggested to play a role in the pathogenesis of various diseases, including age-related macular degeneration and osteoarthritis, by modulating extracellular matrix or cell surface proteins.
|
29695130 |
2018 |
|
Age related macular degeneration
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A promoter variant of the gene encoding HTRA1 is part of a mutant allele that causes increased HTRA1 expression and contributed to age-related macular degeneration (AMD) in genomewide association studies.
|
29730901 |
2018 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A significant genotype and variant allele association was found of rs10490924 in ARMS2/HTRA1 with wet AMD, while the SNPs in CFH, CFB, and C3 were not associated with AMD in the current Pakistani cohort.
|
30895599 |
2019 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
After age and sex adjustment, the odds ratio for risk of AMD was 9.1 (4.0-20.9, 95% CI, p=0.0001) for the AA genotype and 2.6 (1.3-5.5, 95% CI, p=0.04) for the AG genotype, conditional on HTRA1.
|
18079691 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After age and sex adjustment, the odds ratio for risk of AMD was 9.1 (4.0-20.9, 95% CI, p=0.0001) for the AA genotype and 2.6 (1.3-5.5, 95% CI, p=0.04) for the AG genotype, conditional on HTRA1.
|
18079691 |
2007 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
After controlling for established AMD risk factors, including polymorphisms of the genes encoding complement factor H (CFH) and age-related maculopathy susceptibility 2/HtrA serine peptidase (ARMS2/HTRA1), and smoking history, we found that ultraviolet irradiance was protective for the development of neovascular AMD (p = 0.001).
|
22155603 |
2011 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Allele and genotype frequencies of single nucleotide polymorphisms for the following AMD-associated alleles were evaluated: risk alleles in complement factor H (CFH) gene (Y402H and IVS14) and LOC387715/HTRA1 gene on 10q26 (A69S) and protective alleles in CFH (IVS1, IVS6, and delCFHR1-3) and complement factor B loci (H9L and R32Q).
|
19001225 |
2008 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although specific alleles for CFH, ARMS2, HTRA1, and C3 may predict the development of AMD, they did not predict response to anti-vascular endothelial growth factor therapy.
|
23337555 |
2013 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although the closely linked genome-wide association studies ARMS2/HTRA1 genes, located at the chromosome 10q26 locus, are strongly associated with the risk of AMD, their downstream targets are unknown.
|
24497574 |
2014 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among the variants located at the 10q26 region, rs11200638, located at the HTRA1 gene promoter, has been associated with age-related macular degeneration in several populations and is considered the main polymorphism.
|
28846052 |
2018 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Among these, HtrA1 is implicated in several cancers, cerebrovascular disease and age-related macular degeneration.
|
29093542 |
2017 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.
|
19933195 |
2010 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Applying MicroScale Thermophoresis and protease digestion analysis, we demonstrate direct binding and proteolysis of transforming growth factor β1 (TGF-β1) by normal HTRA1 but not the AMD-risk-associated isoform.
|
26310622 |
2015 |
|
Age related macular degeneration
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
ARMS2 and HTRA1 mRNA levels did not show a significant difference in expression among the control (young and elderly) and AMD retinas.
|
20664794 |
2010 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration.
|
21122828 |
2011 |