|
Acute periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In particular, we detected an increase of plasma cell HtrA1 immunostaining from gingivitis to chronic and aggressive periodontitis, with the higher intensity in aggressive disease.
|
24979214 |
2014 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, HtrA1 may be a potential target for overcoming CDDP resistance in LAC.
|
24356998 |
2014 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Highly myopic elderly Japanese patients with and without CNV were genotyped for three AMD-associated single nucleotide polymorphisms (SNPs), namely rs10490924 (rs10490924" genes_norm="387715">A69S) of ARMS2, rs11200638 of HTRA1, and rs1061170 (rs1061170" genes_norm="3075">Y402H) of complement factor H (CFH), with the TaqMan SNP assay.
|
19680273 |
2010 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
This finding is consistent with the role of HTRA1 in AMD pathogenesis and will help aid in the clinical management and prognosis of AMD patients.
|
18206206 |
2008 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Variants within CFH and LOC387715/HTRA1 may contribute to the increased risk of late AMD largely through their impact on precursors, such as drusen and/or other RPE/Bruch's membrane changes.
|
17327825 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD.
|
17053108 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We performed an extensive literature search for studies on the association between AMD and the less studied genetic variants in PLEKHA1/ARMS2/HTRA1.
|
24013816 |
2013 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
SNPs in chromosomal region 10q26 harboring PLEKHA1, ARMS2, and Htra1 showed the strongest association with age-related macular degeneration.
|
19696174 |
2010 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The LOC387715/HTRA1 variants are associated with PCV and wet AMD in the Japanese population.
|
17692272 |
2007 |
|
Age related macular degeneration
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Transgenic zebrafish overexpressing human HTRA1 in rod PRCs showed morphologic changes of the RPE, including PRC death and lipofuscin accumulation, features similar to those of early AMD. htra1 expression was also increased in a retinitis pigmentosa zebrafish model compared with wild type.
|
30273602 |
2018 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The analysis targeted nine genes in these two key regions, including the Complement Factor H (CFH) gene, the 5 CFH-related (CFHR) genes representing a known copy number "hotspot", the F13B gene as well as the ARMS2 and HTRA1 genes in 387 cases of late AMD and 327 controls.
|
22558131 |
2012 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The variant of HTRA1/625G-->A could be a potentially promising genetic biomarker of AMD.
|
19026638 |
2009 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We genotyped three SNPs, rs1061170 (exon 9, CFH), rs11200638 (HTRA1 promoter, -512 bp), and rs10490924 (6.6 kb upstream of HTRA1 in LOC387715/ARMS2) in 333 cases with advanced AMD (choroidal neovascularization [CNV] and geographic atrophy) and 171 age-matched examined controls.
|
18682806 |
2008 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The promoter, splice regions, and coding exons of HTRA1 were sequenced in 163 patients with exudative AMD and 183 sex- and age-matched control subjects.
|
18316707 |
2008 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Contrary to previous reports, we show that rs11200638 SNP has no significant impact on HTRA1 promoter activity in three different cell lines, and HTRA1 mRNA expression exhibits no significant change between control and AMD retinas.
|
17884985 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
CFH and LOC387715/HTRA1 haplotypes and smoking status exerted large effects on AMD susceptibility, enabling risk scores to be generated with appropriate weighting of these three factors.
|
18162041 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association of the SNP at the ARMS2/HTRA1 locus with subretinal/sub-RPE hemorrhage and poorer visual acuity and of SNPs at the CFH locus with drusen area may provide new insights in pathophysiological pathways underlying different stages of AMD.
|
29096998 |
2018 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we confirm that ARMS2, HTRA1 and CFH variants are associated with neovascular AMD in the Thai population.
|
28703135 |
2017 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD.
|
17053108 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
|
23326517 |
2013 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
LHGDN |
In addition, rs11200638 was significantly associated with soft confluent drusen, which are strongly immunolabeled with HTRA1 antibody in an AMD eye with GA similar to wet AMD.
|
17426452 |
2007 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
AMD donors carrying the ARMS2 and HTRA1 risk alleles were the most likely to exhibit elevated CEP markers.
|
19202148 |
2009 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Understanding oxidative stress and HTRA1 locus in abnormal angiogenesis resulting in wet AMD pathology is an important step in developing a novel therapeutic approach.
|
31100080 |
2019 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
After controlling for established AMD risk factors, including polymorphisms of the genes encoding complement factor H (CFH) and age-related maculopathy susceptibility 2/HtrA serine peptidase (ARMS2/HTRA1), and smoking history, we found that ultraviolet irradiance was protective for the development of neovascular AMD (p = 0.001).
|
22155603 |
2011 |