|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration.
|
28775256 |
2017 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of neovascular age-related macular degeneration in the Thai population.
|
28703135 |
2017 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration.
|
27338780 |
2016 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Twelve polymorphisms at the ARMS2-HTRA1 locus showed significant differences between PCV and nAMD.
|
26081444 |
2015 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The risk alleles of CFH rs800292, rs2274700, ARMS2 rs3057847, and ARMS2/HTRA1 rs3793917 showed significant difference between nAMD or PCV patients and controls (all P<0.01).
|
25771815 |
2015 |
|
Exudative age-related macular degeneration
|
0.200 |
Biomarker
|
disease |
BEFREE |
FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy.
|
25277308 |
2014 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The variants in CFH, ARMS2 and near HTRA1 were strongly associated with both PCV (P < 10(-6), 10(-7) and 10(-7) respectively) and nAMD (P < 10(-6), 10(-16) and 10(-17) respectively).
|
23274582 |
2013 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three previously reported associations of response to VEGF inhibition in nAMD involving single nucleotide polymorphisms (SNPs) at the CFH, FZD4, and HTRA1/ARMS2 loci were tested for replication.
|
24070809 |
2013 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There is a strong and consistent association of the ARMS2/HTRA1 locus with both nAMD and PCV, suggesting the two disorders share, at least partially, similar molecular mechanisms.
|
23326481 |
2013 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The NvAMD-associated synonymous polymorphisms lie within HtrA1's putative insulin-like growth factor 1 (IGF-1) binding domain.
|
23478260 |
2013 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
differentiate the associations of exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) with the ARMS2/HTRA1 locus.
|
22491416 |
2012 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration.
|
21558292 |
2012 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese.
|
20538655 |
2010 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association pattern and haplotype estimation in the ARMS2/HTRA1 region of Japanese patients with PCV were very similar to those of Japanese patients with typical nAMD.
|
21191724 |
2010 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age-related macular degeneration in a Korean population.
|
20456446 |
2010 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analyses of single nucleotide polymorphisms and haplotype linkage of LOC387715 and the HTRA1 gene in exudative age-related macular degeneration in a Chinese cohort.
|
19491722 |
2009 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Sequence variants in HTRA1 and LOC387715/ARMS2 and phenotype and response to photodynamic therapy in neovascular age-related macular degeneration in populations from Israel.
|
19065273 |
2008 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genotype-phenotype correlations for exudative age-related macular degeneration associated with homozygous HTRA1 and CFH genotypes.
|
18362109 |
2008 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH.
|
18316707 |
2008 |
|
Exudative age-related macular degeneration
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present study was undertaken to replicate the associations of representative polymorphisms in three genes (complement factor H (CFH), complement factor B (BF) and HtrA serine peptidase 1 (HTRA1)) with exudative age-related macular degeneration (AMD) in a Han Chinese population, and to test if the modifiable environmental factors affect AMD susceptibility associated with different type of genotype in these genes.
|
19187590 |
2008 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population.
|
18939352 |
2008 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration.
|
18164066 |
2008 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population.
|
18682812 |
2008 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of the HTRA1 -625G>A promoter gene polymorphism with exudative age-related macular degeneration in a Central European population.
|
17679948 |
2007 |
|
Exudative age-related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population.
|
17904186 |
2007 |