Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
MGD |
|
|
|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Alzheimer's Disease
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease brain showed strong immunoreactivity of presenilin 1 in reactive astrocytes and senile plaques.
|
10340748 |
1999 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's disease due to an intronic presenilin-1 (PSEN1 intron 4) mutation: A clinicopathological study.
|
10775535 |
2000 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress.
|
10998555 |
2000 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's disease. Molecular consequences of presenilin-1 mutation.
|
11395757 |
2001 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's disease-linked mutations in presenilin-1 (PS-1) reportedly impair ER stress-mediated protective responses and enhance vulnerability to degeneration.
|
11574534 |
2001 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Alzheimer disease-linked Presenilin-1 (PS1) is a negative modulator of beta-catenin/Tcf-4 activity.
|
16306047 |
2006 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease mouse models that overexpress amyloid precursor protein (APP) and presenilin 1 (PS1) form β-amyloid (Aβ) plaques, a hallmark Alzheimer's disease lesion.
|
30315100 |
2018 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's Disease Presenilin-1 Mutation Sensitizes Neurons to Impaired Autophagy Flux and Propofol Neurotoxicity: Role of Calcium Dysregulation.
|
30636740 |
2019 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's Disease Progression in the 5×FAD Mouse Captured with a Multiplex Gene Expression Array.
|
31683485 |
2019 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
|
9485372 |
1998 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Presenilin-1 (PSEN1) mutations I143T and G384A give rise to severe early onset Alzheimers's disease in two extensively studied Belgian families, AD/A and AD/B.
|
10548420 |
1999 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Presenilin 1 (PS1) is required for the proteolytic processing of Notch and the beta-amyloid precursor protein (APP), molecules that play pivotal roles in cell-fate determination during development and Alzheimer's disease pathogenesis, respectively.
|
11517342 |
2001 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Presenilin 1 mutations are the major cause of autosomal dominant Alzheimer's disease: here we identify a new missense mutation causing a methionine to valine change at codon 233.
|
11684347 |
2001 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Presenilin-1 mutations account for nearly 50% of all early-onset familial cases of Alzheimer's disease.
|
11755019 |
2002 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease.
|
11978763 |
2002 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?
|
12706835 |
2003 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Presenilin 1 (PS1) plays a pivotal role in the production of the amyloid-beta protein (Abeta) that is central to the pathogenesis of Alzheimer's disease.
|
14993906 |
2004 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Presenilin 1 (PS1) is mutated in the majority of familial cases of Alzheimer disease (AD).
|
15480879 |
2004 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Presenilin 1 (PS1) and amyloid precursor protein (APP) mutation carriers have a nearly 100% risk of developing AD and may be studied prior to symptom onset.
|
16534109 |
2006 |
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Presenilin-1 (PS1) has gained intensive attention in relation to Alzheimer's disease, since it has been shown that PS1 mutations are linked to familial Alzheimer's disease (FAD), and that PS1 is a member of the high molecular weight complex of gamma-secretase, which generates the carboxyl end of beta-amyloid peptide (gamma-cleavage).
|
16908988 |
2004 |
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins.
|
17545141 |
2007 |