Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.
|
6593703 |
1984 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The human pS2 gene, whose expression is restricted to breast cancer cells, and whose transcription is induced by oestrogen in the human breast cancer cell line MCF-7, has been cloned from both placental and MCF-7 cell DNA.
|
3822834 |
1987 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of the estrogen-induced pS2 protein secreted by the human breast cancer cell line MCF-7.
|
3665845 |
1987 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the pS2 gene, which is induced by estrogen in the breast cancer cell line MCF-7, has been investigated in breast cancers by using pS2 mRNA determination in tumor specimens and immunocytochemistry to identify pS2 protein in paraffin-embedded sections.
|
3321071 |
1987 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene is transcriptionally induced by oestrogen in the human breast cancer cell line MCF-7.
|
2450536 |
1988 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
|
3041593 |
1988 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF-7 is oestrogen independent in stomach mucosa.
|
2498085 |
1989 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients.
|
2583860 |
1989 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene encodes for a small cysteine-rich protein, and was originally found by differential screening of a cDNA library from the human breast carcinoma cell line, MCF-7.
|
2290113 |
1990 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 protein purified from conditioned medium of MCF-7 cells was S-pyridylethylated and digested with TPCK-trypsin.
|
2185238 |
1990 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
|
2303034 |
1990 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the pS2 gene in breast cancer--a comparison of pS2 protein radioimmunoassay and immunohistochemistry.
|
8265245 |
1993 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data clearly indicate that the breast-cancer-associated pS2 protein also plays an as yet undetermined role in the tumorigenesis of human colorectal carcinomas.
|
7505265 |
1994 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The oestrogen-inducible pS2 protein has previously been associated with good prognosis for breast cancer patients.
|
7880621 |
1994 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genomic sequencing indicates a correlation between DNA hypomethylation in the 5' region of the pS2 gene and its expression in human breast cancer cell lines.
|
7607504 |
1995 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA ploidy and pS2 protein expression in breast cancer.
|
9202892 |
1997 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Its sequence is related to that of other trefoil peptides including the pNR-2/pS2 protein, which is regulated by oestrogen in breast cancer.
|
9306961 |
1997 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to determine whether expression of mRNA for the pS2 gene in breast cancer could contribute useful information on disease behaviour and survival at medium-term follow-up.
|
9472649 |
1998 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Regulation of the estrogen-responsive pS2 gene in MCF-7 human breast cancer cells.
|
11162921 |
2000 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pS2 gene product was firstly identified as an oestrogen-induced molecule in a breast cancer cell line, while recent studies demonstrate a close association with mucus-secreting epithelia.
|
10727981 |
2000 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PS2 protein in breast carcinomas: cut-off value of estrogen-regulated expression.
|
11327531 |
2001 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nonetheless, these results collectively suggest that the novel PS-2 alleles described here, especially R71W, affect PS-2 function and may potentially confer a moderate risk of susceptibility to breast cancer.
|
16474849 |
2006 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although E<sub>2</sub> and E<sub>3</sub> were equally efficacious and potent on the endogenous ERE-containing pS2 promoter in the MCF-7 BUS breast cancer cell line co-expressing ERα and ERβ, E<sub>1</sub> was less efficacious and potent than E<sub>2</sub>.
|
28743541 |
2017 |