|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we designed a study to investigate the possible role of resistin gene variation in both obesity and bone mineral density.
|
23203410 |
2013 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese.
|
17223990 |
2007 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resistin is an adipokine that has been considered as a potential factor in obesity-mediated insulin resistance and type 2 diabetes.
|
29730652 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Upregulated expression of resistin, vaspin, apelin and TNF-α plays a significant role in induction of insulin resistance linked with obesity and type 2 diabetes.
|
29229313 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Treatment of human hepatocytes with resistin at levels observed in human obesity stimulated apoB secretion up to 10-fold, because of increased microsomal triglyceride transfer protein (MTP) activity and decreased expression/phosphorylation of proteins in the insulin signaling pathways (insulin receptor substrate-2, Akt, and extracellular signal-regulated kinase).
|
21293001 |
2011 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, resistin is suggested to be an important link between obesity and the development of gastric cancer.
|
24929539 |
2014 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we aimed to examine the expression of resistin (Retn), amylin (Iapp), and dopamine receptor domain 5 (Drd5) genes previously suggested to contribute to the pathogenesis of obesity, albeit controversially.
|
29936463 |
2018 |
|
Obesity
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Our results indicate that SCFA may correct aberrant expressions of adiponectin and resistin in obesity by epigenetic regulation.
|
29925443 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Resistin gene polymorphisms may play an important role in pathogenesis and susceptibility to obesity, impaired glucose tolerance, and type 2 diabetes mellitus in Egyptian population.
|
23178185 |
2013 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Plasma resistin levels decreased following either endurance aerobic exercise and/or resistance training plans in individuals with obesity and/or insulin resistance, although this was not related to BMI change.
|
29498254 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.
|
11809189 |
2002 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Together, these results suggest that these variants in resistin are not associated with obesity in the female population.
|
18239575 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Present study shows that 420C/G polymorphism of resistin gene directly correlated to its high circulating level and metabolic risk factors, specifically markers of obesity and atherosclerosis, so it may have an important role in the development of metabolic syndrome and cardio metabolic diseases.
|
25088792 |
2014 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The adipokine resistin exhibits proinflammatory, proangiogenic and metastatic properties, and evidence suggests that resistin may serve as a prognostic biomarker linking obesity and inflammation to cancer.
|
31719210 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no consistent evidence for association between obesity and the SNPs demonstrating minor allele frequency (MAF) above 0.2 (ADIPOQ: -11377C>G, LEP: -2548C>T, 19A>G, RETN: -1300G>A, -1258C>T, -420C>G).
|
20842437 |
2011 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relation of Circulating Resistin to Insulin Resistance in Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis.
|
31803062 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased serum resistin in adults with prader-willi syndrome is related to obesity and not to insulin resistance.
|
15870134 |
2005 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ADIPOQ, LEP, and RETN gene polymorphisms were associated with obesity parameters in HSHS population.
|
28195351 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the exact function of resistin is unknown, we demonstrated only a weak relationship between resistin and insulin sensitivity in nonobese subjects, indicating that resistin is unlikely to be a major link between obesity and insulin resistance in humans.
|
15070954 |
2004 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the presence of the -420C/G SNP of the resistin gene is associated with increased obesity and metabolic syndrome, although it is not different in subjects at high cardiovascular risk such as patients with myocardial infarction or patients with renal dysfunction compared with controls.
|
17598818 |
2007 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the adipokine genes, LEP, LEPR, and RETN were not associated with obesity susceptibility, whereas ADIPOQ G276T (T vs. G: odds ratio (OR), 1.59; 95% confidence interval (CI), 1.39-1.81), IL-1β C3953T (CC vs. CT+TT: OR, 1.61; 95% CI, 1.18-2.20), and TNF-α G308A (GG vs. GA+AA: OR, 1.19; 95% CI, 1.02-1.39) polymorphisms were associated with an increased risk of obesity.
|
21660081 |
2012 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of resistin and its plasma levels: Association with obesity and dyslipidemia related to type 2 diabetes susceptibility.
|
29969661 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resistin is secreted by rodent fat cells and was recently postulated to be an important link between obesity and insulin resistance.
|
11444881 |
2001 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that RETN gene variation has gender-specific effects on BMI and warrants further investigation of its implications for the development of obesity.
|
15221446 |
2004 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this research was to assess leptin, adiponectin and resistin secretion in obese postmenopausal women with osteoporosis and determine whether obesity might be a factor mitigating the risk of osteoporosis.
|
31566247 |
2019 |