Non-Small Cell Lung Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to determine the frequency of inactivation and clinical correlates in non-small cell lung cancer (NSCLC) of three known tumor suppressor genes [TSGs; RB, MTS1/CDKN2 (p16), and p53] and various regions of 3p loss of heterozygosity (LOH) as other major potential TSG sites.
|
10213214 |
1999 |
Congenital small ears
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Twisted gastrulation can function as a BMP antagonist.
|
11260717 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TSG genetic lesions, such as BRCA1 in breast cancer and p53 in Li-Fraumeni Syndrome, have been identified in both sporadic and heritable human endocrine tumors.
|
11414476 |
2001 |
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
TSG genetic lesions, such as BRCA1 in breast cancer and p53 in Li-Fraumeni Syndrome, have been identified in both sporadic and heritable human endocrine tumors.
|
11414476 |
2001 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
TSG genetic lesions, such as BRCA1 in breast cancer and p53 in Li-Fraumeni Syndrome, have been identified in both sporadic and heritable human endocrine tumors.
|
11414476 |
2001 |
Li-Fraumeni Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
TSG genetic lesions, such as BRCA1 in breast cancer and p53 in Li-Fraumeni Syndrome, have been identified in both sporadic and heritable human endocrine tumors.
|
11414476 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These 3p genetic alterations lead to the conclusion that the short arm of human chromosome 3 contains several tumor suppressor gene(s) (TSG(s)).
|
12362274 |
2002 |
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
To ascertain the involvement of human chromosome 3p and its established critical TSG regions in various epithelial malignancies, 21 polymorphic and 2 nonpolymorphic 3p markers were allelotyped in nonpapillary RCC, NSCLC, CC and BC from a total of 184 patients.
|
12124802 |
2002 |
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
It is clear now that genetic and epigenetic abnormalities of several genes residing in chromosome region 3p are important for the development of lung cancers but it is still obscure how many of them exist and which of the numerous candidate TSGs are the key players in lung cancer pathogenesis.
|
12362274 |
2002 |
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
It is clear now that genetic and epigenetic abnormalities of several genes residing in chromosome region 3p are important for the development of lung cancers but it is still obscure how many of them exist and which of the numerous candidate TSGs are the key players in lung cancer pathogenesis.
|
12362274 |
2002 |
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
It is clear now that genetic and epigenetic abnormalities of several genes residing in chromosome region 3p are important for the development of lung cancers but it is still obscure how many of them exist and which of the numerous candidate TSGs are the key players in lung cancer pathogenesis.
|
12362274 |
2002 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The smallest region homozygously deleted in 3p21.3C was located between D3S1568 (CACNA2D2 gene) and D3S4604 (SEMA3F gene) and contains 17 genes previously defined as lung cancer candidate Tumor suppressor genes (TSG(s)).
|
12771950 |
2003 |
Liver carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Although methylation of one or two genes could be seen in both nontumor and cirrhotic livers, 53% of the HCC cases had three or more TSG promoters methylated, in comparison to 0% in nontumor liver and 13% in cirrhosis (P = 0.001).
|
12937151 |
2003 |
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The smallest region homozygously deleted in 3p21.3C was located between D3S1568 (CACNA2D2 gene) and D3S4604 (SEMA3F gene) and contains 17 genes previously defined as lung cancer candidate Tumor suppressor genes (TSG(s)).
|
12771950 |
2003 |
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The smallest region homozygously deleted in 3p21.3C was located between D3S1568 (CACNA2D2 gene) and D3S4604 (SEMA3F gene) and contains 17 genes previously defined as lung cancer candidate Tumor suppressor genes (TSG(s)).
|
12771950 |
2003 |
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The smallest region homozygously deleted in 3p21.3C was located between D3S1568 (CACNA2D2 gene) and D3S4604 (SEMA3F gene) and contains 17 genes previously defined as lung cancer candidate Tumor suppressor genes (TSG(s)).
|
12771950 |
2003 |
Chronic Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that RFP2, c13ORF1, and a chromosome 13-specific ST13-like gene, FAM10A4, are the most likely candidates for such a type of B-CLL TSG.
|
14499696 |
2003 |
Liver Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although methylation of one or two genes could be seen in both nontumor and cirrhotic livers, 53% of the HCC cases had three or more TSG promoters methylated, in comparison to 0% in nontumor liver and 13% in cirrhosis (P = 0.001).
|
12937151 |
2003 |
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results strongly suggest that 3p21.3T and 3p21.3C regions harbor genes involved in the origin and/or development of CCs and imply that those genes might be multiple TSG(s).
|
12771950 |
2003 |
Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although methylation of one or two genes could be seen in both nontumor and cirrhotic livers, 53% of the HCC cases had three or more TSG promoters methylated, in comparison to 0% in nontumor liver and 13% in cirrhosis (P = 0.001).
|
12937151 |
2003 |
B-CELL MALIGNANCY, LOW-GRADE
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that RFP2, c13ORF1, and a chromosome 13-specific ST13-like gene, FAM10A4, are the most likely candidates for such a type of B-CLL TSG.
|
14499696 |
2003 |
Holoprosencephaly
|
0.320 |
Biomarker
|
disease |
CTD_human |
The mammalian twisted gastrulation gene functions in foregut and craniofacial development.
|
15013800 |
2004 |
Jaw Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
The mammalian twisted gastrulation gene functions in foregut and craniofacial development.
|
15013800 |
2004 |
Arhinencephaly
|
0.300 |
Biomarker
|
disease |
CTD_human |
The mammalian twisted gastrulation gene functions in foregut and craniofacial development.
|
15013800 |
2004 |
Lobar Holoprosencephaly
|
0.300 |
Biomarker
|
disease |
CTD_human |
The mammalian twisted gastrulation gene functions in foregut and craniofacial development.
|
15013800 |
2004 |