Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
It has increasingly been considered crucial the understanding of DNA methylation of Tumor Suppressor Gene (TSG) promoters, such as that of retinoblastoma 1 gene (RB1), and its role during carcinogenesis.
|
29468541 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, all of our findings revealed that TWSG1 maybe serves as a tumor suppressor gene in gastric cancer and potential biomarker or therapeutic target for the diagnosis and treatment of gastric cancer.
|
29756996 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Matrigel assays demonstrated the effect of tumor cell-derived TWSG1 on endothelial cell function.
|
28928871 |
2017 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Furthermore, TET1 catalytic domain possessed demethylase activity in cancer cells, being able to inhibit the CpG methylation of tumor suppressor gene (TSG) promoters and reactivate their expression, such as SLIT2, ZNF382 and HOXA9.
|
27225590 |
2016 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
ROS-induced oxidative stress is associated with both aberrant hypermethylation of tumor suppressor gene (TSG) promoter regions and global hypomethylation.
|
25585126 |
2015 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Here, we aimed to specifically reverse tumor-suppressor gene (TSG) promoter hypermethylation with bovine oocyte extract.
|
23670097 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hypomethylation at three different repetitive DNA (rDNA) sequences and hypermethylation of 12 CpG loci, including 11 tumor suppressor gene (TSG) promoters, were quantified using MethyLight or combined bisulfite restriction analysis.
|
24023736 |
2013 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
In this study we aimed to quantify tumor suppressor gene (TSG) promoter methylation densities levels in primary neuroblastoma tumors and cell lines.
|
22984959 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All subsequent events in that tumour therefore take place on an essentially null background for that TSG protein.
|
18836487 |
2009 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
To investigate whether DNA methylation is abnormal in thymic epithelial tumors (TETs), we analyzed global methylation levels and the methylation status of 9 tumor suppressor gene (TSG) promoters in 65 TET samples.
|
19340654 |
2009 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Aberrant methylation of tumor suppressor gene (TSG) promoters has been extensively investigated in nasopharyngeal carcinomas (NPC) from South East Asia but not from North Africa.
|
18751390 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RASSF1A inhibits tumor growth in both in vitro and in vivo systems, further supporting its role as a TSG.
|
15867337 |
2005 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The smallest region homozygously deleted in 3p21.3C was located between D3S1568 (CACNA2D2 gene) and D3S4604 (SEMA3F gene) and contains 17 genes previously defined as lung cancer candidate Tumor suppressor genes (TSG(s)).
|
12771950 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These 3p genetic alterations lead to the conclusion that the short arm of human chromosome 3 contains several tumor suppressor gene(s) (TSG(s)).
|
12362274 |
2002 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TSG genetic lesions, such as BRCA1 in breast cancer and p53 in Li-Fraumeni Syndrome, have been identified in both sporadic and heritable human endocrine tumors.
|
11414476 |
2001 |