|
Acute leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The MLL gene is fused with the cAMP-responsive element binding protein-binding protein (CBP) gene in t(11;16)(q23;p13), which has been reported to be associated with therapy-related acute leukemia.
|
10706136 |
2000 |
|
Acute leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results provide further evidence for the multiple contribution of both MOZ and CBP genes in acute leukemias.
|
10469454 |
1999 |
|
Acute lymphocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Therefore, specifically inhibiting CBP/catenin transcription represents a novel approach to overcome relapse in ALL.
|
23728349 |
2014 |
|
Acute lymphocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A diagnosis of FA was confirmed by an increased number of chromosomal breaks and rearrangements in peripheral blood lymphocytes cultured with mitogen in the presence of mitomycin C. We conclude that this FA patient developed ALL followed by a therapy-related t(11;16)-AML resulting in an MLL-CBP fusion.
|
10679915 |
2000 |
|
Acute lymphocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
CBP Modulates Sensitivity to Dasatinib in Pre-BCR<sup>+</sup> Acute Lymphoblastic Leukemia.
|
30262461 |
2018 |
|
Acute monoblastic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We show here that a novel t(10;16)(q22;p13) in a childhood AML M5a leads to a MORF-CBP chimera.
|
11157802 |
2001 |
|
Acute monocytic/monoblastic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have developed an RT-PCR strategy that enables us to detect the MOZ-CBP as well as the CBP-MOZ fusions in the two AML M5 with t(8;16)(p11;p13) analyzed.
|
10862050 |
2000 |
|
Acute myelomonocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The translocation t(8;16)(p11;p13) is associated with acute myeloid leukemia displaying monocytic differentiation (AML FAB M4/5) and fuses the MOZ (also named MYST3) gene (8p11) with the CBP (also named CREBBP) gene (16p13).
|
15085163 |
2004 |
|
Acute myelomonocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The CBP gene at 16p13 fuses to MOZ and MLL as a result of the t(8;16)(p11;p13) in acute (myelo)monocytic leukemias (AML M4/M5) and the t(11;16)(q23;p13) in treatment-related AML, respectively.
|
11157802 |
2001 |
|
Acute myelomonocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
The CBP gene was recently identified as a partner gene in the t(8;16) that occurs in acute myelomonocytic leukemia (AML-M4) de novo and rarely in treatment-related acute myeloid leukemia.
|
9226152 |
1997 |
|
Acute Undifferentiated Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation.
|
20541704 |
2010 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.
|
26603525 |
2016 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Simultaneous inhibition of p300/CBP and Notch has a synergistic effect in esophageal adenocarcinoma.
|
28625977 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
GATA3 acetylation at K119 by CBP inhibits cell migration and invasion in lung adenocarcinoma.
|
29453984 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we found that high expression of both CBP and CPSF4 predicted a poor prognosis in the patients with lung adenocarcinomas.
|
26628108 |
2016 |
|
Adenovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results suggest that the p300/CBP-binding domain of E1A inhibits a p53-dependent cellular response which normally inhibits DNA replication following Adenovirus infection.
|
9070653 |
1997 |
|
Adult Acute Lymphocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Therefore, specifically inhibiting CBP/catenin transcription represents a novel approach to overcome relapse in ALL.
|
23728349 |
2014 |
|
Adult Acute Lymphocytic Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A diagnosis of FA was confirmed by an increased number of chromosomal breaks and rearrangements in peripheral blood lymphocytes cultured with mitogen in the presence of mitomycin C. We conclude that this FA patient developed ALL followed by a therapy-related t(11;16)-AML resulting in an MLL-CBP fusion.
|
10679915 |
2000 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene.
|
9166831 |
1997 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the tax-CBP/p300 interaction.
|
11090202 |
2000 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Together, our data raise the possibility that alteration of EID1 expression, particularly the increase of EID1 nuclear localization that inhibits CBP/p300 activity in neuronal cells, may play an important role in AD pathogenesis.
|
22186421 |
2012 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer's disease.
|
25888034 |
2015 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease.
|
21149712 |
2010 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of the KAT families GNAT (KAT2A, KAT2B), p300/CBP (KAT3A, KAT3B), and MYST (KAT5, KAT6A, KAT6B, KAT7, KAT8) was significantly higher in AAA than in controls (P ≤ 0.019).
|
26767057 |
2016 |
|
Ataxia, Spinocerebellar
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This delay was accompanied by stabilization of p300/CBP, transcriptional mediators whose abundance and activity would otherwise decline in the course of the SCA1 disease, and persistence of protein kinase C gamma (PKCgamma), a protein involved in Purkinje cell dendritic development that is mutated in one form of spinocerebellar ataxia.
|
16409551 |
2006 |