|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Clinicopathological detection ascertained that SMURF1-positive expression was associated with large tumor size, more lymph nodes and distant metastasis as well as advanced tumor-node-metastasis (TNM) stage of GC.
|
28731194 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Clinicopathological detection verified that SMURF1 expression was associated with advanced tumor node metastasis stage, large tumor size and vascular invasion of ccRCC patients.
|
28396841 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
The findings of the present study indicated that overexpression of SMURF1 may contribute to the malignancy and metastasis of OC.
|
30542716 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
SMAD ubiquitination regulatory factor-1 (SMURF1) is a C2-WW-HECT-domain E3 ubiquitin ligase that plays important roles in cancer cell metastasis.
|
25631036 |
2015 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
SMAD ubiquitination regulatory factors 1 and 2 (Smurf1/2) are members of the HECT domain E3 ligase family which play crucial roles in the regulation of cell cycle progression, planar cell polarity, cancer metastasis and cell apoptosis.
|
27856247 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
RASSF1A mutants unable to bind RhoA or Smurf1 failed to suppress RhoA-induced tumor cell proliferation, drug resistance, epithelial-mesenchymal transition, migration, invasion, and metastasis.
|
26825171 |
2016 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
This study aimed to investigate the effects of Smurf1 on thyroid cancer proliferation and metastasis, as well as underlying potential mechanism.
|
30244247 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Now, by high-resolution genomic profiling of human pancreatic cancer cell lines and human tumors (engrafted in immunodeficient mice to enrich the cancer epithelial fraction), we define a 325 Kb minimal amplicon spanning SMURF1, an E3 ubiquitin ligase and known negative regulator of transforming growth factor β (TGFβ) growth inhibitory signaling.
|
21887346 |
2011 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
|
25471937 |
2014 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Accumulating studies have shown that SMURF1 acts as an oncogenic factor in human malignancies.
|
28731194 |
2017 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
SMAD ubiquitination regulatory factor 1 (SMURF1) has been described as a tumor suppressor in multiple aggressive cancers.
|
30672020 |
2019 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
However, the regulation and biological function of Smurf1 and Smurf2 in cancer development remain to be elucidated.
|
18927080 |
2008 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The findings of the present study indicated that overexpression of SMURF1 may contribute to the malignancy and metastasis of OC.
|
30542716 |
2019 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.
|
30244169 |
2019 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Finally, we provide scattered clues of regulation of SMURF2 by oncogenic miRNAs, specifically considering longstanding questions related to regulation of SMURF1 and WWPs by miRNAs in BCa.
|
31456194 |
2019 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of Smurf2 in human breast cancer MDA-MB-231 cells resulted in increases in the levels of Smurf1 protein, and enhancement of cell migration in vitro and bone metastasis in vivo.
|
18927080 |
2008 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our study reveals a novel positive feedback between SMURF1 and ER alpha signaling in supporting breast cancer growth.
|
29433542 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results suggest that EGFinduced SMURF1 plays a role in breast cancer cell migration and invasion through the downregulation of RhoA.
|
24241683 |
2013 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our study reveals a novel positive feedback between SMURF1 and ER alpha signaling in supporting breast cancer growth.
|
29433542 |
2018 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results suggest that EGFinduced SMURF1 plays a role in breast cancer cell migration and invasion through the downregulation of RhoA.
|
24241683 |
2013 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of Smurf2 in human breast cancer MDA-MB-231 cells resulted in increases in the levels of Smurf1 protein, and enhancement of cell migration in vitro and bone metastasis in vivo.
|
18927080 |
2008 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.
|
30244169 |
2019 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Finally, we provide scattered clues of regulation of SMURF2 by oncogenic miRNAs, specifically considering longstanding questions related to regulation of SMURF1 and WWPs by miRNAs in BCa.
|
31456194 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Clinicopathological detection verified that SMURF1 expression was associated with advanced tumor node metastasis stage, large tumor size and vascular invasion of ccRCC patients.
|
28396841 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Notably, GC patients with SMURF1 positive‑expressing tumors exhibited a significant decreased survival.
|
28731194 |
2017 |