|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Nuclear and cytoplasmic KIAA1199 protein expression was identified in colon adenocarcinomas and other types of cancers.
|
21772334 |
2011 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In normal mucosa, KIAA1199 expression was confined to cells in the lower portion of intestinal crypts, where Wnt signaling is physiologically active, but it was markedly increased in all adenomas, where it was expressed in most of the epithelial cells, and in colon cancer cell lines, it was markedly reduced by inactivation of the beta-catenin/T-cell factor(s) transcription complex, the pivotal mediator of Wnt signaling.
|
18171984 |
2007 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Plasma KIAA1199 RNA levels were significantly higher in patients with either cancer or adenoma (31/40) compared to neoplasia-free controls (6/20).
|
22276102 |
2012 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Results showed that CEMIP was overexpressed in human and murine OA cartilage and along chondrocytes dedifferentiation.
|
30718510 |
2019 |
|
Anaplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
KIAA1199: A novel regulator of MEK/ERK-induced Schwann cell dedifferentiation.
|
28699206 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, little is known about the functional significance of KIAA1199 in PDAC.
|
28179576 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis revealed high expression of KIAA1199 in 26 (26.5%) of 98 PDAC tissues.
|
28012880 |
2017 |
|
Benign neoplasm of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that the expression of KIAA1199 in human colorectal tumors (benign and malignant) is markedly higher than that in the normal colonic mucosa.
|
23936024 |
2013 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Involvement of DNA methylation in regulation of KIAA1199 expression was recapitulated in human breast cancer cell lines.
|
22970280 |
2012 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, an immortal fibroblast cell line and two breast cancer cell lines expressed much lower amounts of KIAA1199 mRNA than their normal counterparts.
|
16157444 |
2006 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data suggest H3K27me3 loss as an important event in CEMIP mediated breast cancer carcinogenesis and progression.
|
31846842 |
2020 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
To gain deeper insights into the novel role of KIAA1199 in breast cancer, we modulated KIAA1199 expression using shRNA-mediated knockdown in two breast cancer cell lines (MDA-MB-231 and HS578T), expressing higher levels of KIAA1199.
|
24628760 |
2014 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
CEMIP is a cell migration-inducing protein that is closely associated with carcinogenesis.
|
30925458 |
2019 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
It has been suggested that cell migration inducing hyaluronan binding protein (CEMIP) contributes to the carcinogenesis of colorectal cancer (CRC).
|
29024602 |
2018 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Our transcriptomic profiles of normal colonic mucosa and colorectal adenomas shed new light on the early stages of colorectal tumorigenesis and identified KIAA1199 as a novel target of the Wnt signaling pathway and a putative marker of colorectal adenomatous transformation.
|
18171984 |
2007 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Cell migration inducing hyaluronan binding protein (CEMIP) is a hyaluronic acid binding protein, the abnormal elevation of which is suggested as a contributor in the carcinogenesis of colorectal cancer (CRC).
|
29173982 |
2018 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that KIAA1199 gene may play a role in cellular mortality of normal human cells, which counters cell immortalization and carcinogenesis.
|
16157444 |
2006 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Central Role of CEMIP in Tumorigenesis and Its Potential as Therapeutic Target.
|
28819426 |
2017 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
H3K27me3 loss plays a vital role in CEMIP mediated carcinogenesis and progression of breast cancer with poor prognosis.
|
31846842 |
2020 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, these data suggest that CEMIP may promote the development of ovarian cancer by regulating PI3K/AKT signaling.
|
30925458 |
2019 |
|
Colon Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In normal mucosa, KIAA1199 expression was confined to cells in the lower portion of intestinal crypts, where Wnt signaling is physiologically active, but it was markedly increased in all adenomas, where it was expressed in most of the epithelial cells, and in colon cancer cell lines, it was markedly reduced by inactivation of the beta-catenin/T-cell factor(s) transcription complex, the pivotal mediator of Wnt signaling.
|
18171984 |
2007 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We present CEMIP as a candidate prognostic marker for colon cancer and a potential therapeutic target.
|
26437221 |
2015 |
|
Colonic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results demonstrate that CEMIP directly facilitates colon tumor growth, and high CEMIP expression correlates with poor outcome in stage III and in stages II+III combined cohorts.
|
26437221 |
2015 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Furthermore, CEMIP silencing sensitized CRC cells to thapsigargin-induced apoptosis.
|
29024602 |
2018 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Collectively, KIAA1199 plays a critical role in maintaining an aggressive phenotype of tumor cells, and suppression of KIAA1199-related motilities of tumor cells contributes to reduced tumor metastasis in colorectal cancer.
|
28213952 |
2017 |