|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In RT-PCR analysis, RET/PTC was found in 28.6% (4/14) of tumors.
|
19495791 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further, many cell lines have lost the expression of thyroid-specific genes and have altered karyotypes, while they exhibit activation of several oncogenes (BRAF, v-raf murine sarcoma viral oncogene homolog B1; RAS, rat sarcoma; and RET/PTC, rearranged in transformation/papillary thyroid carcinoma) and inactivation of tumor suppressor gene (TP53) which is known to be important for thyroid tumorigenesis.
|
20001716 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Real-time LightCycler RT-PCR detected RET/PTC in 12 and Southern blot analysis in 11 tumors.
|
16772343 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Insights into the molecular biology of the tumor have come from looking at alterations in the genes altered in these syndromes, PTC and APC, respectively.
|
15256053 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of CD82 and CD63 was analysed by reverse transcriptase-PCR (RT-PCR) and immunohistochemistry in benign goiter (n=12) and 75 primary thyroid carcinoma tissue specimens (PTC: 33, FTC: 24, UTC: 18) out of which 36 were non-metastasized primary tumors and 39 were metastasized tumors (regional lymph node and/or distant metastases).
|
15375577 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although ret/PTC rearrangements have been identified in both spontaneous and radiation-induced papillary thyroid cancer, they seem more frequent among radiation-associated tumors.
|
15126554 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These tumors contain a predominantly follicular growth pattern but display nuclear features and overall clinical behavior consistent with PTC.
|
15188460 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
RET/PTC rearrangements are believed to be tumor-initiating events in papillary thyroid carcinomas.
|
14555660 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No significant correlation was observed between the frequency and/or the type of RET/PTC rearrangement and clinical-epidemiological features of the patients such as age at diagnosis, age at exposure, histological variant, gender and tumor-node-metastasis (TNM) categories.
|
11443191 |
2001 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
An H-ras 13 mutation was found in 1 metastatic tumor and an N-ras 61 mutation in 1 intrathyroidal tumor. ret/PTC was identified in 3 intrathyroidal and 5 metastatic tumors.
|
9889797 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We tested a resulting prediction that RET/PTC expression in thyroid epithelium should be sufficient to cause the changes in nuclear morphology diagnostic of this tumor.
|
9811335 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The prevalence of ret/PTC in these tumors varies widely, from 0% to 87%, among patient series from different geographical regions.
|
9669285 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The percentage of proliferating cells was significantly different among the histotypes, increasing with tumour aggressiveness (from the mean value of 3.1 for PTC to 5.6 for PDC and 51.8 for UC).
|
9052406 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggest that inactivation of some tumor suppressor gene(s) on 9q other than PTC contributes to the development of squamous cell carcinomas in these tissues.
|
9140104 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression.
|
8658145 |
1996 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We analyzed 60 thyroid carcinomas for ret/PTC expression to determine correlation with clinical history, disease stage, or tumor morphology.
|
8784097 |
1996 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We did not find any ret transcripts in papillary carcinomas negative for PTC activation, nor in normal thyroid and in non-papillary thyroid neoplasias.
|
1457350 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis by a reverse transcriptase-polymerase chain reaction method showed that the ret rearrangement-positive tumor contained the PTC/retTPC chimeric transcript, which was reported to be found specifically in thyroid tumors and adenomatous goiter.
|
1381340 |
1992 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The same structural alterations of PTC and TRK (gene rearrangements) as well as of N-RAS (point mutation) detected in the NIH3T3 transformants, were also found in the original tumour DNAs, thus indicating that their activation was not due to transfection procedures.
|
2594368 |
1989 |