Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Up-regulation of miR-146a and miR-146b expression in tissues was related to carcinogenesis and deterioration of PTC.
|
25524940 |
2015 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The differences in nuclear architecture and spatial positioning of genes involved in RET/PTC rearrangements between human and rodent thyroid cells raise a concern about suitability of animal models for assessing RET/PTC-driven thyroid carcinogenesis in humans.
|
22136268 |
2011 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Further, many cell lines have lost the expression of thyroid-specific genes and have altered karyotypes, while they exhibit activation of several oncogenes (BRAF, v-raf murine sarcoma viral oncogene homolog B1; RAS, rat sarcoma; and RET/PTC, rearranged in transformation/papillary thyroid carcinoma) and inactivation of tumor suppressor gene (TP53) which is known to be important for thyroid tumorigenesis.
|
20001716 |
2009 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results suggest that RET/PTC rearrangements play an important role in radiation-associated thyroid carcinogenesis.
|
18757433 |
2008 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In fact, it has been demonstrated that: a) RET/PTC is an early event in the process of thyroid carcinogenesis and has a critical role in the generation of the papillary carcinoma; b) RET/PTC activation is essentially restricted to the papillary histotype and to the Hürthle thyroid tumors; c) its incidence increases after exposure to radiations.
|
17891236 |
2007 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis.
|
16946010 |
2007 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results indicate that the variability in c-RET and RET/PTC mRNA levels contributes to the apparent inconsistencies in their reported detection rates and should be taken into account not only for diagnostic purposes but also to better understand the role of c-RET activation in thyroid tumorigenesis.
|
15502856 |
2004 |
Carcinogenesis
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
In conclusion, RET/PTC-induced tyrosine phosphorylation of PDK1 may be one of the mechanisms by which it acts as an oncogenic tyrosine kinase in thyroid carcinogenesis.
|
12738763 |
2003 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The proposed mechanisms of RET/PTC-induced tumorigenesis and the clinical and pathologic implications of RET/PTC activation are discussed.
|
11707626 |
2001 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The frequency, if we consider exclusively the papillary carcinomas, is in both cases 12%; (b) show that the TRK oncogene plays a role in the development of a minority of radiation-associated papillary thyroid carcinomas but not in adenomas; and (c) confirm that RET/PTC rearrangements are the major genetic alteration associated with ionizing radiation-induced thyroid tumorigenesis.
|
10646882 |
2000 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our results indicate that RET/PTC oncogene rearrangements may play a role in early-stage papillary thyroid carcinogenesis, but they seem to be less important in determining progression to clinically-evident disease.
|
9814501 |
1998 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate the possible role of the PTC gene on chromosome 9q22.3, that was identified as the cause of nevoid basal cell carcinoma syndrome, during carcinogenesis in esophagus and lung, we examined 20 esophageal squamous cell carcinomas and 10 squamous cell carcinomas of the lung for mutations in any coding exon of PTC.
|
9140104 |
1997 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
RET/PTC oncogene activation is an early event in thyroid carcinogenesis.
|
7566982 |
1995 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study questions the relevance of PTC/retTPC oncogene in the carcinogenesis of thyroid papillary carcinomas in the Saudi population.
|
8275421 |
1994 |