PTCH1, patched 1, 5727

N. diseases: 604; N. variants: 194
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.320 Biomarker disease BEFREE To investigate whether the Hedgehog signaling pathway is also active in human pancreatic adenocarcinomas, we determined the expression levels of the known Hedgehog target genes PTCH1 and GLI-1 in pancreatic tumors. 22076568 2012
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.320 Biomarker disease CTD_human The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. 19077462 2009
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.320 GeneticVariation disease BEFREE Mutations in the smoothened (SMOH) gene and loss-of-function mutations in the patched (PTCH) gene, which are involved in the HH signaling pathway, may cause pancreatic tumors. 19232458 2009