PTCH1, patched 1, 5727

N. diseases: 604; N. variants: 194
Disease: Neuroectodermal Tumor, Primitive ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 Biomarker disease MGD Protective role of 17 β-estradiol on medulloblastoma development in Patched 1 heterozygous mice. 21351254 2010
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 Biomarker disease MGD Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. 19185848 2009
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 Biomarker disease MGD A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. 17047082 2006
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 Biomarker disease MGD The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. 16260494 2005
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 Biomarker disease MGD Hair cycle regulation of Hedgehog signal reception. 12648487 2003
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 Biomarker disease MGD High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice. 12386820 2002
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 Biomarker disease BEFREE Thus, PTCH is the only gene in this complex pathway that is mutated with notable frequency in PNET. 10564585 2000
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 Biomarker disease CTD_human Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. 9581815 1998
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.520 GeneticVariation disease BEFREE We have analyzed 9 sporadic BCCs and 37 PNETs for mutation and expression of the PTCH gene. 9205058 1997