Diabetic Retinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of miR-21 and PI3K/Akt/VEGF related genes, along with a reduced expression of PTEN was observed in the retinal tissues of DR rats.
|
31759996 |
2020 |
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Results revealed that increased hyperalgesia was concurrent with an increment of Iba1 (P < 0.001), TNF-α (P < 0.001), PTEN (P < 0.01), cleaved caspase-3 (P < 0.001), and a decrement of P.Akt (P < 0.01) during the acute phase of CFA-induced inflammation, while, at the same time as decreasing hyperalgesia during the chronic phase of study, Iba1 and TNF-α expression significantly decreased and PTEN, cleaved caspase-3, and P.Akt restored to baseline on day 0.
|
31388881 |
2020 |
Hyperlipidemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
When hyperlipidemia is induced in mice with the podocyte-specific deletion of PTEN, these mice recapitulate the major pathophysiologic features of ORG.
|
31813249 |
2020 |
Otitis Media
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results indicate that both AKT and PTEN are mediators of mucosal growth during OM, and could be potential therapeutic targets.
|
31837294 |
2020 |
Pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Besides, miR-214-3p up-regulation was showed to inhibit PTEN expression but increased P-Akt levels in the HP kidney, which might be a possible mechanism to induce severe symptoms of pancreatitis.
|
31790686 |
2020 |
Pulmonary Sclerosing Hemangioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Further study of PTEN mutation in sclerosing pneumocytoma is warranted.
|
31166879 |
2020 |
Carcinoma of urinary bladder, invasive
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although miR-200a has been reported as an onco-miRNA that targets the PTEN gene in endometrioid carcinoma, its biological significance in BC invasion has been poorly explored.
|
31772330 |
2020 |
NONAKA MYOPATHY
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, treatment with ERβ agonist DPN (5 nM) significantly decreased the inhibitory effect of a PTEN knockdown on tamoxifen response of both cell lines (p < 0.05).
|
31604073 |
2020 |
Infectious Otitis Media
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results indicate that both AKT and PTEN are mediators of mucosal growth during OM, and could be potential therapeutic targets.
|
31837294 |
2020 |
Minimal hepatic encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oridonin prevents insulin resistance-mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy.
|
31568638 |
2020 |
Obesity Related Glomerulopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, PTEN downregulation in podocytes may contribute to the pathogenesis of ORG.
|
31813249 |
2020 |
Acute pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Rosiglitazone pretreatment prevented AP progression through suppression of miR-26a expression via binding to and degrading PTEN.
|
31363368 |
2019 |
Cholera
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore we showed that miR132-3p<sup>+</sup> greatly induced the endocytosis of cholera toxin subunit B and FITC-bovine serum albumin and up-regulated the expression of p-PKB, p-Src and Tyr14 phosphorylation of caveolin-1 (p-Cav-1), while phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression was markedly down-regulated in GECs.
|
30024792 |
2019 |
Diabetic Angiopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
The effects of metformin on improving PA‑induced EPC dysfunction are mediated by miR‑130a and PTEN, which may assist in the prevention and/or treatment of diabetic vascular disease.
|
30896786 |
2019 |
Enterovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
miR-545 promoted enterovirus 71 replication via directly targeting phosphatase and tensin homolog and tumor necrosis factor receptor-associated factor 6.
|
30697739 |
2019 |
Fetal Growth Retardation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Reductions of GLUT4 as well as increases of PTEN and nuclear fractional PPARγ were detected in IUGR offsprings.
|
31071176 |
2019 |
Hypercholesterolemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, ezetimibe suppressed development of liver tumors by inhibiting angiogenesis in Pten<sup>Δhep</sup> mice with hypercholesterolemia.
|
30520543 |
2019 |
Immune System Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Loss of PTEN activity in human and mice is associated with cellular and humoral immune dysfunction, lymphoid hyperplasia, and autoimmunity.
|
31501268 |
2019 |
Influenza
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Single Cell Profiling Reveals PTEN Overexpression in Influenza-Specific B cells in Aging HIV-infected individuals on Anti-retroviral Therapy.
|
30792481 |
2019 |
Ketosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
PTEN negatively regulates the enzymes involved in hepatic gluconeogenesis and lipid synthesis, which suggests that PTEN may be a therapeutic target for ketosis and fatty liver in dairy cows.
|
30819264 |
2019 |
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Based on the important functions of phosphatase and tensin homolog (PTEN)-Long for renal diseases, the present study aimed to investigate the expression of PTEN-Long in patients and mice with nephritis and its effect on nephritis.
|
30680021 |
2019 |
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that JAK2 and PTEN are pivotal to the development of trigeminal neuropathic pain, and that JAK2 and PTEN suppression alleviates the neuropathic pain.
|
31454541 |
2019 |
Obesity, Morbid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We present a patient with morbid obesity who carries a known pathogenic PTEN mutation, identified at the bariatric surgery clinic using an obesity gene panel consisting of 52 obesity-associated genes.
|
31055886 |
2019 |
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis.
|
30656849 |
2019 |
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, lncRNA TUG1 is upregulated in osteoporosis and regulates the proliferation and apoptosis of osteoclasts. lncRNA TUG1 knockdown may serve as a promising therapeutic target for osteoporosis by inhibiting the proliferation and promoting the apoptosis of osteoclasts through PTEN.
|
31815638 |
2019 |