Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Loss of heterozygosity of the 10q23 region is a frequent event in malignant EPTs and might suggest several hypotheses: a different tumor suppressor gene in the vicinity of PTEN might be principally involved in EPT formation; alternatively, 10q loss, including PTEN, seems to be associated with malignant transformation, but the first step toward neoplasia might involve altered subcellular localization of PTEN.
|
11021813 |
2000 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Close association between oral papillomatosis associated with Cowden syndrome and PTEN gene mutation may increase the risk for malignant transformation.
|
28396890 |
2017 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We conclude that PTEN may have played a less prognostic role than p53 in the development and malignant transformation of STS in the patients examined.
|
22052239 |
2012 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Endometriosis is characterized by genetic instability: like neoplasms endometriosis seems to be monoclonal in origin, several studies have documented loss of heterozygosity (LOH) in endometriosis, data suggest that mutation of the tumor suppressor gene PTEN play a part in the malignant transformation of endometriosis, some studies have revealed TP53 mutations in endometriotic lesions, and mutation of ARID1A seems to be an important early event in the malignant transformation of endometriosis to endometrioid and clear cell carcinomas.
|
22032835 |
2012 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The analysis of PTEN in various forms of endometriosis and its malignant transformation may help in understanding the early steps of tumorigenesis.
|
16343215 |
2006 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The value of this finding as a predictor of malignant transformation in endometriosis must still be clarified and further studied in association with other molecular events, such as PTEN (phosphatase and tensin homolog) deletion and PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) mutation.
|
26832958 |
2016 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In primary rat embryo fibroblasts, PTEN also inhibited malignant transformation mediated by ras and c-myc oncogenes.
|
11497285 |
2001 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The purpose of the current study was to characterize the role of PTEN in malignant transformation and to evaluate the significance of mutated PTEN exons as prognostic markers in the carcinogenesis of endometrial hyperplasia.
|
15385114 |
2004 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis.
|
25051360 |
2014 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
PTEN dosage is essential for neurofibroma development and malignant transformation.
|
19846776 |
2009 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results indicate that the oncogenic capacity of HIF-1α in regulation of miR-21-inhibited PTEN in a manner dependent on the Akt/NF-κB pathway, a process that is involved in the CSE-induced malignant transformation of HBE cells.
|
29501572 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
PTEN is critical to prevent the malignant transformation of T-cells.
|
31064074 |
2019 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Herein, we demonstrate excessive CUDR cooperates with excessive CyclinD1 or PTEN depletion to accelerate liver cancer stem cells growth and liver stem cell malignant transformation in vitro and in vivo.
|
26513297 |
2015 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
PTEN is a protein phosphatase that is crucial to prevent the malignant transformation of T-cells.
|
26616857 |
2016 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
They also show that a bi-allelic inactivation of PTEN can lead to developmental anomalies instead of malignant transformation, thus raising the question of the limitations of the tumor suppressive function in this gene.
|
17392703 |
2007 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In this report, we analyzed the methylation status of hMLH1 and p16 and the protein expression of PTEN and hMLH1 in 46 cases of endometriosis stages III and IV to better define the possible involvement of these genes in the malignant transformation of endometriosis.
|
12402310 |
2002 |